| 查看: 520 | 回复: 1 | |||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | |||
huqionghhkk木虫 (小有名气)
|
[求助]
翻译一段（药物化学）
|
||
|
A widely used method to judge compounds for drug discovery is the “rule of 5” (RO5) (6), which predicts poor absorption or permeation for compounds that deviate from property-value constraints: H-bond donors (Hd) and acceptors (Ha), molecular weight (MW), and calculated partition coefficients (cLogP). Recent studies have attempted to refine such rules (7–9) and extend them to other goals (10–13), such as making leads or probes. Such property filters have been debated and reviewed (14–16), and their long-term impact on pharmaceutical research is starting to be analyzed (17, 18). Importantly, exceptions to these rules, including natural products (19–21), are well-noted and suggest that previously undescribed types of chemistry might access property distributions acceptable for certain goals despite nonadherence to established rules. |
回复此楼» 猜你喜欢
国家级人才课题组招收2026年入学博士
已经有4人回复
-
青年基金C终止
已经有4人回复
-
青椒八年已不青，大家都被折磨成啥样了？
已经有7人回复
-
为什么nbs上溴 没有产物点出现呢
已经有10人回复
-
救命帖
已经有11人回复
-
招博士
已经有5人回复
-
26申博求博导推荐-遥感图像处理方向
已经有4人回复
-
限项规定
已经有7人回复
-
西南交通大学国家级人才团队2026年博士研究生招生（考核制）—机械、材料、力学方向
已经有3人回复
-
英文综述是否需要润色及查重
已经有5人回复
sltmac
荣誉版主 (知名作家)
- 翻译EPI: 161
- 应助: 10 (幼儿园)
- 贵宾: 4.557
- 金币: 29307.8
- 散金: 2687
- 红花: 47
- 沙发: 4
- 帖子: 5424
- 在线: 633.4小时
- 虫号: 996442
- 注册: 2010-04-14
- 性别: GG
- 专业: 无机纳米化学
- 管辖: 论文翻译
2楼2011-06-06 19:42:06