| 查看: 1084 | 回复: 9 | |||
| 当前主题已经存档。 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
ermopi金虫 (正式写手)
|
[交流]
这一篇重点介绍了实际应用的pd催化C-N＆C-O键的形成反应！
|
||
|
这一篇重点介绍了实际应用的pd催化C-N＆C-O键的形成反应！ Topics in Current Chemistry,Vol. 219 Practical Palladium Catalysts for C-N and C-O Bond Formation The development of new palladium catalysts for the arylation of amines and alcohols with aryl halides and sulfonates is reviewed. Initial systems as well as mechanistic issues are discussed briefly,while subsequent generations of catalysts are described in greater detail.For these later generations of catalysts, substrate scope and limitations are also discussed.The review is organized by substrate class. Modifications and improvements in technical aspects of reaction development are described where appropriate. In addition, applications of this technology toward natural product synthesis, new synthetic methodology, and medicinal chemistry are chronicled. This review is organized in a manner that is designed to be useful to the synthetic organic chemist. Keywords. Amination, Arylation, Catalyst, Ligand, Palladium 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133 2 Palladium-Catalyzed Amine Arylation . . . . . . . . . . . . . . . . 134 2.1 Initial Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 134 2.2 N-Arylation of Secondary Amines . . . . . . . . . . . . . . . . . . . 136 2.2.1 Reaction of Cyclic Secondary Amines with Aryl Bromides . . . . . 136 2.2.2 Reaction of Secondary Amines with Aryl Bromides . . . . . . . . . 143 2.2.3 Reaction of Diarylamines with Aryl Bromides . . . . . . . . . . . . 148 2.2.4 Reaction of Secondary Amines with Aryl Iodides . . . . . . . . . . 150 2.2.5 Reaction of Cyclic Secondary Amines with Aryl Chlorides . . . . . 151 2.2.6 Reaction of Acyclic Secondary Amines with Aryl Chlorides . . . . 154 2.2.7 Reaction of Cyclic Amines with Aryl Sulfonates . . . . . . . . . . . 157 2.2.8 Reaction of Secondary Acyclic Amines with Aryl Sulfonates . . . . 159 2.3 N-Arylation of Primary Amines . . . . . . . . . . . . . . . . . . . . 160 2.3.1 Reaction of Primary Aliphatic Amines with Aryl Bromides . . . . . 160 2.3.2 Reaction of Primary Aromatic Amines with Aryl Bromides . . . . 165 2.3.3 Reaction of Primary Amines with Aryl Iodides . . . . . . . . . . . 171 2.3.4 Reaction of Primary Aliphatic Amines with Aryl Chlorides . . . . . 172 2.3.5 Reaction of Primary Arylamines with Aryl Chlorides . . . . . . . . 174 2.3.6 Reaction of Primary Aliphatic Amines with Aryl Sulfonates . . . . 176 2.3.7 Reaction of Primary Arylamines with Aryl Sulfonates . . . . . . . . 177 2.4 Arylation of Ammonia Equivalents . . . . . . . . . . . . . . . . . . 179 2.5 Arylation of Amides and Carbamates . . . . . . . . . . . . . . . . . 183 2.6 Arylation of Nitrogen-Containing Heterocycles . . . . . . . . . . . 184 2.7 Arylation of Other Nitrogen Substrates . . . . . . . . . . . . . . . . 187 2.8 Heteroaryl Halides in the Pd-Catalyzed Amine Arylation . . . . . . 190 2.9 Intramolecular Arylation of Amines and Amides . . . . . . . . . . 194 2.9.1 Intramolecular Arylation of Amines . . . . . . . . . . . . . . . . . 194 2.9.2 Intramolecular Arylation of Amides . . . . . . . . . . . . . . . . . 197 3 Palladium-Catalyzed Alcohol Arylation . . . . . . . . . . . . . . . 198 3.1 Reaction of Aliphatic Alcohols . . . . . . . . . . . . . . . . . . . . . 198 3.2 Reaction of Phenol Derivatives . . . . . . . . . . . . . . . . . . . . 201 3.3 Intramolecular Arylation of Alcohols . . . . . . . . . . . . . . . . . 203 4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204 5 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205 [ Last edited by wxwdoctor on 2007-3-25 at 19:46 ] |
回复此楼» 猜你喜欢
河南一本高校化学，材料，化工专业招收研究生
已经有0人回复
-
大连海事大学船舶洁净能源研究中心2026年博士研究生招生启事
已经有10人回复
-
化学工程及工业化学论文润色/翻译怎么收费?
已经有228人回复
-
双一流大学湘潭大学“化工过程模拟与强化”国家地方联合工程研究中心招收各类博士生
已经有14人回复
-
2026年湘潭大学接收化学工程与技术相关方向学术型硕士研究生调剂生
已经有1人回复
-
双一流大学湘潭大学“化工过程模拟与强化”国家地方联合工程研究中心招收博士生
已经有13人回复
-
一志愿天津大学 材料与化工358 求调剂
已经有1人回复
-
2026湖北师范大学化学化工学院招收硕士研究生调剂
已经有0人回复
-
2026湖北师范大学化学化工学院招收研究生调剂
已经有0人回复
-
2026湖北师范大学化学化工学院硕士研究生调剂
已经有0人回复
rabbit7708
荣誉版主 (职业作家)
心虫
- 应助: 0 (幼儿园)
- 贵宾: 3.109
- 金币: 6404.6
- 红花: 10
- 帖子: 3094
- 在线: 5.9小时
- 虫号: 76692
- 注册: 2005-06-25
- 性别: GG
- 专业: 催化
- 管辖: 催化
8楼2006-10-22 12:53:57
feieronly
金虫 (初入文坛)
- 应助: 0 (幼儿园)
- 金币: 557.9
- 帖子: 19
- 在线: 2.3小时
- 虫号: 280486
- 注册: 2006-09-17
- 性别: MM
- 专业: 理论和计算化学
4楼2006-10-08 10:14:46
5楼2006-10-08 11:09:08
6楼2006-10-22 11:54:40
5