| 查看: 1354 | 回复: 9 | |||
| 当前主题已经存档。 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
ermopi金虫 (正式写手)
|
[交流]
这一篇重点介绍了实际应用的pd催化C-N＆C-O键的形成反应！
|
||
|
这一篇重点介绍了实际应用的pd催化C-N＆C-O键的形成反应！ Topics in Current Chemistry,Vol. 219 Practical Palladium Catalysts for C-N and C-O Bond Formation The development of new palladium catalysts for the arylation of amines and alcohols with aryl halides and sulfonates is reviewed. Initial systems as well as mechanistic issues are discussed briefly,while subsequent generations of catalysts are described in greater detail.For these later generations of catalysts, substrate scope and limitations are also discussed.The review is organized by substrate class. Modifications and improvements in technical aspects of reaction development are described where appropriate. In addition, applications of this technology toward natural product synthesis, new synthetic methodology, and medicinal chemistry are chronicled. This review is organized in a manner that is designed to be useful to the synthetic organic chemist. Keywords. Amination, Arylation, Catalyst, Ligand, Palladium 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133 2 Palladium-Catalyzed Amine Arylation . . . . . . . . . . . . . . . . 134 2.1 Initial Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 134 2.2 N-Arylation of Secondary Amines . . . . . . . . . . . . . . . . . . . 136 2.2.1 Reaction of Cyclic Secondary Amines with Aryl Bromides . . . . . 136 2.2.2 Reaction of Secondary Amines with Aryl Bromides . . . . . . . . . 143 2.2.3 Reaction of Diarylamines with Aryl Bromides . . . . . . . . . . . . 148 2.2.4 Reaction of Secondary Amines with Aryl Iodides . . . . . . . . . . 150 2.2.5 Reaction of Cyclic Secondary Amines with Aryl Chlorides . . . . . 151 2.2.6 Reaction of Acyclic Secondary Amines with Aryl Chlorides . . . . 154 2.2.7 Reaction of Cyclic Amines with Aryl Sulfonates . . . . . . . . . . . 157 2.2.8 Reaction of Secondary Acyclic Amines with Aryl Sulfonates . . . . 159 2.3 N-Arylation of Primary Amines . . . . . . . . . . . . . . . . . . . . 160 2.3.1 Reaction of Primary Aliphatic Amines with Aryl Bromides . . . . . 160 2.3.2 Reaction of Primary Aromatic Amines with Aryl Bromides . . . . 165 2.3.3 Reaction of Primary Amines with Aryl Iodides . . . . . . . . . . . 171 2.3.4 Reaction of Primary Aliphatic Amines with Aryl Chlorides . . . . . 172 2.3.5 Reaction of Primary Arylamines with Aryl Chlorides . . . . . . . . 174 2.3.6 Reaction of Primary Aliphatic Amines with Aryl Sulfonates . . . . 176 2.3.7 Reaction of Primary Arylamines with Aryl Sulfonates . . . . . . . . 177 2.4 Arylation of Ammonia Equivalents . . . . . . . . . . . . . . . . . . 179 2.5 Arylation of Amides and Carbamates . . . . . . . . . . . . . . . . . 183 2.6 Arylation of Nitrogen-Containing Heterocycles . . . . . . . . . . . 184 2.7 Arylation of Other Nitrogen Substrates . . . . . . . . . . . . . . . . 187 2.8 Heteroaryl Halides in the Pd-Catalyzed Amine Arylation . . . . . . 190 2.9 Intramolecular Arylation of Amines and Amides . . . . . . . . . . 194 2.9.1 Intramolecular Arylation of Amines . . . . . . . . . . . . . . . . . 194 2.9.2 Intramolecular Arylation of Amides . . . . . . . . . . . . . . . . . 197 3 Palladium-Catalyzed Alcohol Arylation . . . . . . . . . . . . . . . 198 3.1 Reaction of Aliphatic Alcohols . . . . . . . . . . . . . . . . . . . . . 198 3.2 Reaction of Phenol Derivatives . . . . . . . . . . . . . . . . . . . . 201 3.3 Intramolecular Arylation of Alcohols . . . . . . . . . . . . . . . . . 203 4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204 5 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205 [ Last edited by wxwdoctor on 2007-3-25 at 19:46 ] |
回复此楼» 猜你喜欢
求助共晶分子筛的电镜图分析，有偿
已经有1人回复
-
中南大学化学化工学院招收电池储能、理论计算方向博士生
已经有16人回复
-
物理化学论文润色/翻译怎么收费?
已经有61人回复
-
风电环氧领域
已经有3人回复
-
请问哪里可以代烧带压力的炉子？
已经有6人回复
-
关于合成MIL-125的求助
已经有0人回复
-
双非本硕光催化方向想读博，请各位老师看看我！
已经有2人回复
-
瑞典林雪平大学范立洲课题组现招聘博士后、岗位制博士生
已经有0人回复
-
中国科大仿生界面材料科学全国重点实验室戴懿涛研究员/江雷院士团队招聘科研助理
已经有0人回复
-
中国科大仿生界面材料科学全国重点实验室戴懿涛研究员/江雷院士团队招聘科研助理
已经有0人回复
-
寻求物理化学学报最新的投稿模板！
已经有4人回复
5楼2006-10-08 11:09:08
feieronly
金虫 (初入文坛)
- 应助: 0 (幼儿园)
- 金币: 557.9
- 帖子: 19
- 在线: 2.3小时
- 虫号: 280486
- 注册: 2006-09-17
- 性别: MM
- 专业: 理论和计算化学
4楼2006-10-08 10:14:46
6楼2006-10-22 11:54:40
rabbit7708
荣誉版主 (职业作家)
心虫
- 应助: 0 (幼儿园)
- 贵宾: 3.109
- 金币: 6404.6
- 红花: 10
- 帖子: 3094
- 在线: 5.9小时
- 虫号: 76692
- 注册: 2005-06-25
- 性别: GG
- 专业: 催化
- 管辖: 催化
8楼2006-10-22 12:53:57
