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【答案】应助回帖
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Mally89(金币+2): 同上！~O(∩_∩)O~ 2011-05-31 10:56:52
落迦(金币+10, 翻译EPI+1): 谢谢了 2011-05-31 20:02:48
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Surprisingly, we show that the post-transcriptional regulator, EIF2S3, is consistently highlighted across all six tissues examined: the gene was nearly three times over-expressed in male dogs compared to females, in all the tissues studied.转录后调控子EIF2S3令人惊讶地在所有试验的六种组织中均很突出：其基因在雄性犬中表达几乎是雌性犬的3倍之多。 This nding should be contrasted with the observation that the vast majority of genes showed no difference and for those where differences were found it was limited to one or two tissues. 这种情形与绝大多数基因在不同性别不表现出差异或既就是有差异也局限于一或两种组织中的的情形形成鲜明对照。Thus, the discovery that EIF2S3 showed such large differences (common to all the tissues studied), was an intriguing nding. 因此，EIF2S3表达的巨大差异是一个有趣的现象。Pathway analysis showed tissue- specic gender dimorphic proles are apparent between male and female canines; interestingly, EIF2S3 appeared to play a key role in these pathways. 通路分析显示在雄性和雌性犬之间的组织特异性性别二态性proles是显著的；非常有趣的是EIF2S3似乎在这些通路中发挥着重要作用。High homology with the human EIF2S3 raises the prospect of an analogous role for sex-differences in humans.犬与人EIF2S3基因具有高度同源性，这使得这一基因在人类（药物毒性）性别差异研究方面显示很好的前景。 |
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