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[求助]
急！！！求助药理论文摘要翻译 要求语句很通顺
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Canis familiaris, the domestic dog, is a key animal species for preclinical drug development, including toxicity assessment. As data relating to gender dimorphic toxicity in the clinic emerge, the topic of sex differences in relation to drug toxicity will increase in prominence. Much of the emerging clinical data cannot easily be explained by body weight or body fat differences – hence the gender differences may be related to more complex hormonal and/or potential underlying gene expression differences. The dog also demonstrates some gender differences in drug-induced toxicity; hence, in the current study, we investigated differences at the gene expression level between male and female dogs in selected tissues of relevance to toxicity. We attempted to elucidate whether key gene expression differences do exist and if so, whether these gender differences may potentially impact on disease states, drug metabolism and toxicity. We investigated gene expression in the heart (the ventricle and atrium) along with the main tissues of drug absorption, metabolism and excretion, namely, the GI tract (ileum), liver and kidney (medulla and cortex) and performed in silico pathway analysis to elucidate key pathways possibly affected by gender dimorphic expression proles. Surprisingly, we show that the post-transcriptional regulator, EIF2S3, is consistently highlighted across all six tissues examined: the gene was nearly three times over-expressed in male dogs compared to females, in all the tissues studied. This nding should be contrasted with the observation that the vast majority of genes showed no difference and for those where differences were found it was limited to one or two tissues. Thus, the discovery that EIF2S3 showed such large differences (common to all the tissues studied), was an intriguing nding. Pathway analysis showed tissue- specic gender dimorphic proles are apparent between male and female canines; interestingly, EIF2S3 appeared to play a key role in these pathways. High homology with the human EIF2S3 raises the prospect of an analogous role for sex-differences in humans. [ Last edited by 落迦 on 2011-5-30 at 22:11 ] |
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8814402
至尊木虫 (职业作家)
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【答案】应助回帖
★ ★
Mally89(金币+2): 同上！~O(∩_∩)O~ 2011-05-31 10:56:52
落迦(金币+10, 翻译EPI+1): 谢谢了 2011-05-31 20:02:48
Mally89(金币+2): 同上！~O(∩_∩)O~ 2011-05-31 10:56:52
落迦(金币+10, 翻译EPI+1): 谢谢了 2011-05-31 20:02:48
| Surprisingly, we show that the post-transcriptional regulator, EIF2S3, is consistently highlighted across all six tissues examined: the gene was nearly three times over-expressed in male dogs compared to females, in all the tissues studied.转录后调控子EIF2S3令人惊讶地在所有试验的六种组织中均很突出：其基因在雄性犬中表达几乎是雌性犬的3倍之多。 This nding should be contrasted with the observation that the vast majority of genes showed no difference and for those where differences were found it was limited to one or two tissues. 这种情形与绝大多数基因在不同性别不表现出差异或既就是有差异也局限于一或两种组织中的的情形形成鲜明对照。Thus, the discovery that EIF2S3 showed such large differences (common to all the tissues studied), was an intriguing nding. 因此，EIF2S3表达的巨大差异是一个有趣的现象。Pathway analysis showed tissue- specic gender dimorphic proles are apparent between male and female canines; interestingly, EIF2S3 appeared to play a key role in these pathways. 通路分析显示在雄性和雌性犬之间的组织特异性性别二态性proles是显著的；非常有趣的是EIF2S3似乎在这些通路中发挥着重要作用。High homology with the human EIF2S3 raises the prospect of an analogous role for sex-differences in humans.犬与人EIF2S3基因具有高度同源性，这使得这一基因在人类（药物毒性）性别差异研究方面显示很好的前景。 |
3楼2011-05-31 09:28:36
8814402
至尊木虫 (职业作家)
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★ ★
Mally89(金币+2): 感谢应助！~ 2011-05-31 10:56:19
落迦(金币+20): OK了 非常感谢 2011-05-31 20:03:20
Mally89(金币+2): 感谢应助！~ 2011-05-31 10:56:19
落迦(金币+20): OK了 非常感谢 2011-05-31 20:03:20
| Canis familiaris, the domestic dog, is a key animal species for preclinical drug development, including toxicity assessment. 家犬是临床前药物研发包括毒性评价中常用的主要实验动物。As data relating to gender dimorphic toxicity in the clinic emerge, the topic of sex differences in relation to drug toxicity will increase in prominence. 由于在临床中出现性别不同毒性相左的资料，与药物毒性相关的性别差异问题越来越显现出其重要性。Much of the emerging clinical data cannot easily be explained by body weight or body fat differences – hence the gender differences may be related to more complex hormonal and/or potential underlying gene expression differences. 由于性别差异可能与更复杂的激素和/或潜在的基因表达差异，许多新出现的资料并不能简单地通过体重或体内脂肪的差异来解释。The dog also demonstrates some gender differences in drug-induced toxicity; hence, in the current study, we investigated differences at the gene expression level between male and female dogs in selected tissues of relevance to toxicity. 家犬也在药物毒性方面表现出性别差异。We attempted to elucidate whether key gene expression differences do exist and if so, whether these gender differences may potentially impact on disease states, drug metabolism and toxicity. 我们试图阐明是否确实存在关键基因表达差异，如果存在差异，这些差异是否潜在地对疾病状态、药物代谢和毒性产生影响。We investigated gene expression in the heart (the ventricle and atrium) along with the main tissues of drug absorption, metabolism and excretion, namely, the GI tract (ileum), liver and kidney (medulla and cortex) and performed in silico pathway analysis to elucidate key pathways possibly affected by gender dimorphic expression proles.我们研究了心脏（心室和心房）以及药物吸收、代谢和排泄有关的主要器官组织如消化道（回肠）、肝和肾（髓质和皮质）的基因表达，通过计算机通路分析来阐明可能被性别二态性表达所影响的关键通路。 |
2楼2011-05-31 09:02:16
zhaochenchuo
金虫 (小有名气)
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★ ★ ★
Mally89(金币+3): 感谢应助并鼓励新虫！~欢迎常来！~ 2011-05-31 10:57:16
落迦(金币+20): 谢谢了 2011-05-31 20:03:00
Mally89(金币+3): 感谢应助并鼓励新虫！~欢迎常来！~ 2011-05-31 10:57:16
落迦(金币+20): 谢谢了 2011-05-31 20:03:00
| Canis familiaris, the domestic dog, is a key animal species for preclinical drug development, including toxicity assessment. 家犬是临床前药物研究（包括毒性评估）所用主要动物物种。As data relating to gender dimorphic toxicity in the clinic emerge, the topic of sex differences in relation to drug toxicity will increase in prominence.根据临床研究中两性别毒性数据，与药物相关的性别毒性差异将显著增加。 Much of the emerging clinical data cannot easily be explained by body weight or body fat differences – hence the gender differences may be related to more complex hormonal and/or potential underlying gene expression differences. 这些临床数据中大部分不能简单地用体重或机体脂肪差异来解释，由于基因表达的不同，性别差异可能与更复杂的激素和/或蛋白质相关。The dog also demonstrates some gender differences in drug-induced toxicity; hence, in the current study, we investigated differences at the gene expression level between male and female dogs in selected tissues of relevance to toxicity. 药物所致毒性研究中，犬类也表现出了一些性别差异，所以当前研究中我们研究了雌雄两性犬与毒性相关组织中基因表达水平的差异。We attempted to elucidate whether key gene expression differences do exist and if so, whether these gender differences may potentially impact on disease states, drug metabolism and toxicity.我们想要解释主要基因表达是否存在差异，如果存在，这些性别差异是否可能影响疾病状态、药物代谢和毒性。 We investigated gene expression in the heart (the ventricle and atrium) along with the main tissues of drug absorption, metabolism and excretion, namely, the GI tract (ileum), liver and kidney (medulla and cortex) and performed in silico pathway analysis to elucidate key pathways possibly affected by gender dimorphic expression proles.我们通过计算机分析研究了心脏（心房、心室）和药物吸收、代谢和消除主要组织即消化道（回肠）、肝脏和肾脏（髓质和皮质）中基因表达情况，来解释关键通路可能受性别差异表达特征的影响。 |
4楼2011-05-31 10:47:29
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