24小时热门版块排行榜

返回列表

本帖产生 1 个翻译EPI ，点击这里进行查看

我是小兵

铜虫 (小有名气)

应助: 0 (幼儿园)
金币: 102.4
散金: 27
帖子: 77
在线: 11.2小时
虫号: 744312
注册: 2009-04-09
性别: GG
专业: 药物化学

[求助] 各位帮忙把这段英文文献翻译成中文专业有机化学

4.5. Palladium-Catalyzed Kumada Cross-Coupling Reactions
with Alkylmagnesium Reagents
In 1975, Murahashi and co-workers were the ﬁrst to demonstrate the use of Pd in cross-coupling reactions of vinyl halides with CH3MgBr. Despite signiﬁcant advances in Ni-and Fe-catalyzed Kumada cross-couplings, Pd-catalyzed alkyl
Kumada cross-couplings are limited. This could be attributed to the high reactivity of Grignard reagents and the higher propensity of Pd-alkyl species to undergo β-hydride elimination compared to the corresponding nickel-alkyl species.
4.5.1. C(sp2)-C(sp3) Cross-Coupling with Alkylmagne-
sium Reagents. In 1984, Hayashi and co-workers strated a significant effect of ligand bite angle on the reaction outcome for primary and secondary alkyl Grignards and zinc reagents (see section 2.3).The use of dppf as ligand gave
optimal results for both primary and secondary alkyl Grignards.
Since this initial report, dppf has become a very common ligand
in both Pd-catalyzed Kumada and Negishi coupling reactions.

[ Last edited by 我是小兵 on 2011-5-25 at 23:18 ]

回复此楼

» 猜你喜欢

1楼 2011-05-24 20:35:06

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

8814402

至尊木虫 (职业作家)

翻译EPI: 509
应助: 18 (小学生)
贵宾: 0.381
金币: 12916.1
散金: 47
红花: 16
帖子: 4183
在线: 357.8小时
虫号: 1184404
注册: 2011-01-06
专业: 药物学其他科学问题

【答案】应助回帖

★ ★ ★ ★ ★ ★ ★ ★ ★ ★
我是小兵(金币+10, 翻译EPI+1): xiexie 2011-05-26 23:08:13
sltmac(金币+10): 谢谢~~ 2011-05-29 19:59:55

4.5. Palladium-Catalyzed Kumada Cross-Coupling Reactions with Alkyl magnesium Reagents 烷基镁存在下的钯催化Kumada交叉偶联反应
In 1975, Murahashi and co-workers were the ﬁrst to demonstrate the use of Pd in cross-coupling reactions of vinyl halides with CH3MgBr.1975年，Murahashi及其同事最先演示了甲基溴化镁存在下钯在乙烯基卤化物偶联反应中应用。Despite signiﬁcant advances in Ni-and Fe-catalyzed Kumada cross-couplings, Pd-catalyzed alkyl Kumada cross-couplings are limited. 尽管镍和铁催化的Kumada交叉偶联反应取得了重大的进展，把催化的烷基Kumada交叉偶联反应还是有限的。This could be attributed to the high reactivity of Grignard reagents and the higher propensity of Pd-alkyl species to undergo hydride elimination compared to the corresponding nickel-alkyl species.这可以归结于格氏试剂的高反应性和钯烷基类反应相比镍烷基类反应更高的进行β-氢化消除的倾向。
4.5.1. C(sp2)-C(sp3) Cross-Coupling with Alkylmagnesium Reagents. 烷基镁存在下的C(sp2)-C(sp3)交叉偶联反应
In 1984, Hayashi and co-workers strated a significant effect of ligand bite angle on the reaction outcome for primary and secondary alkyl Grignards and zinc reagents (see section 2.3). 1984年，Hayashi 及其同事阐明了配位咬合角对初级和次级格氏和锌试剂反应结果的重要影响。The use of dppf as ligand gave optimal results for both primary and secondary alkyl Grignards. 使用二茂铁为配体，对初级和次级烷基格氏试剂都得到了优化的结果。Since this initial report, dppf has become a very common ligand in both Pd-catalyzed Kumada and Negishi coupling reactions.从这份最初的报道开始，二茂铁逐渐成为在钯催化的Kumada 和 Negishi偶联反应中都很常用的配体。

赞一下(2人)