| 查看: 139 | 回复: 1 | |||
| 当前主题已经存档。 | |||
[交流]
实在找不到，急用！
|
|||
|
Preclinical safety studies of cefmetazole. Moe JB, Piper RC, Tanase H, Sotani K, Manabe J. Upjohn Company, Kalamazoo, Michigan 49001. In order to assess the safety of cefmetazole, preclinical multiple-dose parenteral studies, varying from one to three months in length, were conducted in Sprague-Dawley rats and beagle dogs. Although the largest doses used were in multiples of several times the weight-adjusted doses intended for humans, cefmetazole was generally well tolerated. The principal adverse effect noted in the adult rats receiving the largest doses (2000 and 2500 mg/kg/day) of cefmetazole was slight elevation of serum alanine aminotransferase. Infant rats injected subcutaneously with 300 mg/kg/day or more of cefmetazole for 35 consecutive days had reversible reductions in testicular weight and maturation of spermatogenesis, but not lasting discernible effect on reproductive function. The most consistent effects of longterm multiple dosing with cefmetazole in dogs consisted of vomiting and retching during dosing and reversible haematological changes (mild regenerative anaemia, positive Coombs' test, clinically-silent thrombocytopenia) in a number of the dogs. These findings supported the interpretation that cefmetazole was acceptably safe for clinical studies in humans. PMID: 2722719 [PubMed - indexed for MEDLINE] 我的E-MAIL：zw1159@163.com |
回复此楼» 猜你喜欢
售SCI一区文章，我:8.O.55.1.O.54,科目齐全,可伽急
已经有3人回复
-
售SCI文章，我:8O5.5.1.O.54,科目齐全,可+急
已经有3人回复
-
售SCI一区文章，我:8.O.551.O.5.4,科目全,可伽急
已经有3人回复
-
售SCI文章，我:8O5.5.1.O.54,科目齐全,可+急
已经有3人回复
-
售SCI一区T0P文章，我:8O.55.1.O.5.4,科目齐全,可+急
已经有5人回复
-
售SCI-T0P文章，我:8O.5.5.1.O.54,科目齐全,可+急
已经有7人回复
-
上海工程技术大学 激光智能制造课题组 2027级博士研究生招生
已经有6人回复
-
课题组招2027级博士 上海工程技术大学 激光智能制造方向
已经有6人回复
-
师弟论文见刊大半年才想起来申请专利，还能抢救一下吗？
已经有4人回复
-
有机合成以后会不会被AI改变？做科研的虫友怎么看
已经有8人回复
|
本帖内容被屏蔽 |
2楼2006-09-25 11:49:34