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hummer

荣誉版主 (职业作家)

人美在羽毛，鸟美在心灵

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注册: 2005-05-27
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专业: 学前教育学
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[交流] 外语版hummer求一段话的翻译＋理解

We have shown that paclitaxel-loadedpoly (lactic-co-glycolic acid) (PLGA) nanoparticles could be 5.64 times more effective than that for Taxol® after 24 hour culture will HT-29 cells (a colon cancer cell line) at the same drug concentration. In vivo pharmacokinetics measurements confirmed the advantages of the nanoparticle formulation versus Taxol®. The plasma concentration of the nanoparticle formulation had an area-under-the-curve (AUC) value comparable with that of Taxol®, but never exceeded the maximum tolerance level and hence should have much lesser sideeffects than Taxol®. The nanoparticle formulation had a sustainable therapeutic time of 168 hours in comparison with 22 hours for Taxol® and achieved four times greater drug tolerance than Taxol®.

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