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洗脱剂金虫 (小有名气)
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[求助]
如何下载外文会议文献
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| 最近要下载的文献有两篇是ACS National Meeting的文献，怎么能下到全文，谢谢大家帮忙！ |
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洗脱剂
金虫 (小有名气)
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- 专业: 天然药物化学
3楼2011-05-04 20:15:52
cfm877
铁杆木虫 (知名作家)
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4楼2011-05-04 20:17:27
洗脱剂
金虫 (小有名气)
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5楼2011-05-04 20:22:01
cfm877
铁杆木虫 (知名作家)
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洗脱剂(金币+1): 摘要我下到了，没有全文啊！不管怎样，谢谢！ 2011-05-05 18:00:48
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实在搞不定，只查到了摘要 Synthesis, SAR and biological evaluation of racemic abyssinone II and analogs as potential aromatase inhibitors for prevention of breast cancer. Maiti, Arup; Cuendet, Muriel; Croy, Vicki L.; Endringer, Denise C.; Pezzuto, John M.; Cushman, Mark. Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Cancer Center, Purdue University, West Lafayette, IN, USA. Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007 (2007), MEDI-093. Publisher: American Chemical Society, Washington, D. C CODEN: 69JAUY Conference; Meeting Abstract; Computer Optical Disk written in English. AN 2007:295526 CAPLUS Abstract Aromatase, which converts androgens to estrogens and catalyzes the transformation of pro-carcinogens to carcinogenic metabolites, is an attractive target for the chemoprevention of breast cancer. Inhibitors of aromatase show an overall superior efficacy over selective estrogen receptor modulators (SERMs), a std. therapy used in the treatment of estrogen-receptor-pos. breast cancer in postmenopausal women. Previous studies showed that (S)-abyssinone, isolated from Broussonetia papyrifera L., is a potent aromatase inhibitor. An efficient approach to the synthesis of racemic abyssinone II and a series of its analogs as well as their biol. evaluation as potential selective aromatase inhibitors are described. Racemic abyssinone II showed an IC50 value of 28.0 .mu.M by fluorimetric assay. Several novel racemic analogs displayed increased aromatase inhibitory activity relative to abyssinone II, with IC50 values starting from as low as 1.9 .mu.M. A structure-activity (SAR) model was established to search for new potent chemopreventive agents. This research was supported by program project grant P01 CA48112 funded by the NCI. |
6楼2011-05-04 20:35:41