| ²é¿´: 701 | »Ø¸´: 2 | |||
| ±¾Ìû²úÉú 1 ¸ö ·ÒëEPI £¬µã»÷ÕâÀï½øÐв鿴 | |||
| µ±Ç°Ö»ÏÔʾÂú×ãÖ¸¶¨Ìõ¼þµÄ»ØÌû£¬µã»÷ÕâÀï²é¿´±¾»°ÌâµÄËùÓлØÌû | |||
[ÇóÖú]
ÕâÒ»¶Î»°£¬ÈçºÎ·ÒëºÃÄØ£¿£¨Ó¢ÖУ©
|
|||
|
The invention is directed to a frozen pharmaceutical formulation suitable for administration to a subject parenterally£¬comprising a therapeutically effective amount of tigecycline£¨tigecycline£¬Ò»ÖÖÒ©Î and an agent selected from the group consisting of lactose £¬dextrose£¬glucose £¬mannose£¬surcose £¬ribose£¬xylose and a combination thereof £¬wherein the formulation in a pre-frozen atate at about 22¡æ . or in an unfrozen state at about 22¡æ. has a pH in the range from 4.0 to 5.5. Preferably £¬the formulation is suitable for storage at or below about -20¡æ. over a period of at least about 2 months £¬preferably 6months £¬more preferably 26 months . Alternatively£¬the formulation is suitable for storage at about 22¡æ.over a period of about 24h¡£ |
» ²ÂÄãϲ»¶
ÊÛSCIÒ»ÇøÎÄÕ£¬ÎÒ:8.O.55.1.O.54,¿ÆÄ¿ÆëÈ«,¿ÉÙ¤¼±
ÒѾÓÐ3È˻ظ´
ÊÛSCIÒ»ÇøÎÄÕ£¬ÎÒ:8.O.551.O.5.4,¿ÆÄ¿È«,¿ÉÙ¤¼±
ÒѾÓÐ6È˻ظ´
Ã÷ÌìÓ¦¸Ã¿É²éÁË£¡£¿
ÒѾÓÐ5È˻ظ´
Èç¹û´Ë¿ÌÄãÕýÔÚΪ¹ú»ù¸Ðµ½½¹ÂÇ£¬²»·ÁÀ´ÌýÌýÕâÊס¶»ù½ðÖ®Íâ¡·
ÒѾÓÐ7È˻ظ´
ûÓÐÈκÎÏûÏ¢-ÊDz»ÊǾÍÁ¹ÁË
ÒѾÓÐ8È˻ظ´
ÊÛSCI-T0PÎÄÕ£¬ÎÒ:8O.5.5.1.O.54,¿ÆÄ¿ÆëÈ«,¿É+¼±
ÒѾÓÐ3È˻ظ´
ÈËÆø²»ÐÐÁË
ÒѾÓÐ10È˻ظ´
ÎÒÃæÉÏÍêµ°ÁË
ÒѾÓÐ10È˻ظ´
ÄÜ·ñÍ˳ö²ÎÓëµÄÃæÉÏÏîÄ¿½â³ýÏÞÏî
ÒѾÓÐ24È˻ظ´
filecode£¬4¸öjtjcÁË
ÒѾÓÐ17È˻ظ´

slz146
ľ³æ (ÕýʽдÊÖ)
- ·ÒëEPI: 75
- Ó¦Öú: 0 (Ó×¶ùÔ°)
- ¹ó±ö: 0.055
- ½ð±Ò: 1657.8
- É¢½ð: 966
- ºì»¨: 7
- Ìû×Ó: 713
- ÔÚÏß: 225.5Сʱ
- ³æºÅ: 1097156
- ×¢²á: 2010-09-13
¡¾´ð°¸¡¿Ó¦Öú»ØÌû
À¼·è×Ó(½ð±Ò+20, ·ÒëEPI+1): 2011-04-18 19:03:19
|
Õâ¸öרÀû·¢Ã÷Á˱ù¶³Ò©ÎïÅä·½£¬Ê¹³¦Î¸Ò©Æ·ºÜÊʺϿڷþ£¬´¦·½°üÀ¨¾ßÓÐÒ»¶¨ÖÎÁÆÐ§¹ûµÄÌæ¼Ó»·ËØÒÔ¼°´ÓÏÂÁÐÊÔ¼ÁÑ¡ÔñµÄÒ»ÖÖ»ò½áºÏÆðÀ´µÄ£¨ÈéÌÇ£¬ÓÒÐýÌÇ£¬ÆÏÌÑÌÇ£¬¸Ê¶ÌÇ£¬ÕáÌÇ £¬ºËÌÇ£¬Ä¾ÌÇ£©¡£±ù¶³Ç°´¦·½´¢´æÔÚ22¡æµÄµØ·½£¬»òÕß´óÔ¼22¡æÎª±ù¶³µÄ״̬£¬pH´ó¸ÅΪ4.5-5.5¡£ ´¦·½¾¡Á¿´¢´æÔÚ-20¡æµÄµØ·½£¬±ù¶³Ê±¼ä×îÉÙΪ2¸öÔ£¬¾¡Á¿6¸öÔ£¬26¸öÔ¸üºÃ¡£ µ±È»£¬´¦·½Ò²¿ÉÒÔ´¢´æÔÚ22¡æµÄµØ·½£¬Ê±¼äԼΪ24h¡£ |
3Â¥2011-04-18 13:44:44
shuaishuai90
Òø³æ (СÓÐÃûÆø)
- ·ÒëEPI: 5
- Ó¦Öú: 0 (Ó×¶ùÔ°)
- ½ð±Ò: 443.4
- É¢½ð: 15
- Ìû×Ó: 176
- ÔÚÏß: 30.3Сʱ
- ³æºÅ: 1151774
- ×¢²á: 2010-11-20
- ÐÔ±ð: MM
- רҵ: ÌìȻҩÎﻯѧ

2Â¥2011-04-18 10:32:23









»Ø¸´´ËÂ¥
20