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The invention is directed to a frozen pharmaceutical formulation suitable for administration to a subject parenterally£¬comprising a therapeutically effective amount of tigecycline£¨tigecycline£¬Ò»ÖÖÒ©Î and an agent selected from the group consisting of lactose £¬dextrose£¬glucose £¬mannose£¬surcose £¬ribose£¬xylose and a combination thereof £¬wherein the formulation in a pre-frozen atate at about 22¡æ . or in an unfrozen state at about 22¡æ. has a pH in the range from 4.0 to 5.5. Preferably £¬the formulation is suitable for storage at or below about -20¡æ. over a period of at least about 2 months £¬preferably 6months £¬more preferably 26 months . Alternatively£¬the formulation is suitable for storage at about 22¡æ.over a period of about 24h¡£ |
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- ×¢²á: 2010-11-20
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