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slz146

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【答案】应助回帖

sltmac: 烦请LZ及时对应助评分，谢谢合作~~~ 2011-04-18 20:32:16
沉潜涵咏(金币+2, 翻译EPI+1): 2011-04-18 23:03:45

Hetero atoms which had large electronegativity were introduced in quinary heteroaromatic rings or quinary heteroaromatic rings were substituted benzene rings , this resulted that hydrophobicity decreased or steric effect increased , and this reduced or blockd Hydrophobic Interaction of TTDs and combined bag of reverse transcriptase , thus made activation decrease even disappear . So reorganization of five-membered rings in TTDs molecules was the key that acquired the NNRTIs of TTDs of high activity .

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