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sltmac(½ð±Ò+20): 2011-04-17 12:35:32
Detection of biologically active compounds most commonly used methods are: liquid, gas, UV spectrophotometer, fluorescence methods such as, but high-throughput screening of compounds, the fluorescence detection method is an efficient, fast, easy and free Other substances interfere with the benefits. This article with fluorescent probe, soluble epoxide enzyme inhibitory activity of thiourea compounds for high throughput screening. The latter experiments show the feasibility of this method to obtain good inhibitory effect of some new compounds.
3Â¥2011-04-15 11:20:16
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sltmac(½ð±Ò+30, ·­ÒëEPI+1): »¶Ó­³£À´~~~ 2011-04-17 12:35:26
This paper involves the following aspects:
(¢ñ) the synthesis of thiourea Derivatives£»
(¢ò) the synthesis of fluorescent probes £»
(¢ó)the  Establishment Of Detection method and Its Detection of soluble epoxide hydrolase activity £»
In recent years, with research of the soluble epoxide hydrolase structure and mechanism of action, the soluble epoxide hydrolase activity was further clarified and variety of cardiovascular diseases and inflammationmay be treated. So far, several generations of inhibitors has been studied£¬but poor   water-soluble, poor stability, and poor selectivity were still existed.Therefore£¬ Continue to develop new inhibitors of soluble epoxide hydrolase has become a hot research.On the base of  Previous work and access to a large number of literatures.
The thesis Designs and synthesizes a series of thiourea compounds.
2Â¥2011-04-15 11:19:42
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