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sltmac(金币+30, 翻译EPI+1): 欢迎常来~~~ 2011-04-17 12:35:26
This paper involves the following aspects:
(Ⅰ) the synthesis of thiourea Derivatives；
(Ⅱ) the synthesis of fluorescent probes ；
(Ⅲ)the Establishment Of Detection method and Its Detection of soluble epoxide hydrolase activity ；
In recent years, with research of the soluble epoxide hydrolase structure and mechanism of action, the soluble epoxide hydrolase activity was further clarified and variety of cardiovascular diseases and inflammationmay be treated. So far, several generations of inhibitors has been studied，but poor water-soluble, poor stability, and poor selectivity were still existed.Therefore， Continue to develop new inhibitors of soluble epoxide hydrolase has become a hot research.On the base of Previous work and access to a large number of literatures.
The thesis Designs and synthesizes a series of thiourea compounds. |
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