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fbook

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抗菌肽（antibacterial peptides）是一种由微生物、植物、无脊椎动物和各种动物的细胞和组织产生的一种抗菌活性多肽，也是生物体内先天免疫系统中的重要组成部分。因具有独特的抗菌机理有望成为替代抗生素成为新一代的抗微生物新药。但来源问题始终是抗菌肽研究和利用的瓶颈，为了解决抗菌肽的来源问题，本文通过生物工程的技术和方法在大肠杆菌中成功表达出了有抗菌活性的抗菌肽LNK-16。
首先利用生物信息的方法，在NCBI上找到抗菌活性高、抗菌谱广和分子量小的含有13个氨基酸残基具有线性结构牛的抗菌肽Indolicidin。为了实现抗菌肽Indolicidin在大肠杆菌中表达，通过在N端加入激肽释放酶的氨基酸识别位点（PFR），形成新的多肽命名为LNK-16。人工合成新的多肽LNK-16，抗菌活性检测表明仍具有抗菌活性。

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1楼 2011-04-07 08:10:07

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zs626

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fbook(金币+100, 翻译EPI+1): 100 2011-04-07 22:02:42

Antibacterial peptides are a kind of polypeptide with antimicrobial activity produced by microorganisms, plants, invertebrates, and various animal cells and tissues, whic h are important component of innate immune system of biosystem in vivo. Due to their distinct antibacterial mechanism of antibiosis, antibacterial peptides are expected to become the next generation of anti-microbial drugs. But the source of antibacterial peptides has always been the bottleneck of their researches and utilizations. In order to solve the problem of their source, this paper successfully expressed antimicrobial peptides LNK-16 with antimicrobial activity with bio-engineering techniques and methods.

At first, with the methods of bioinformation, we found the cattle antibacterial peptide Indolicidin with high antibacterial activity, broad antibacterial spectrum, low molecular weight and linear structure in the database of NCBI, which containing 13 amino acid peptides. In order to achieve the expression of Indolicidin in E.coli, by adding amino acid recognition sites of kallikrein (PFR) at the N terminal，we synthesized the new peptide named LNK-16. The detection of antibacterial activity showed that LNK-16 also had antibacterial activity.

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