24小时热门版块排行榜

返回列表

biomill8358

无虫 (小有名气)

应助: 0 (幼儿园)
金币: -3
帖子: 58
在线: 6.5小时
虫号: 689651
注册: 2009-01-08

[交流] 【分享】RNA介导的核体成核作用

Nucleation of nuclear bodies by RNA
RNA介导的核体成核作用
Sergey P. Shevtsov1 & Miroslav Dundr
Nature Cell Biology Volume: 13, Pages: 167–173 Year published: (2011) DOI: doi:10.1038/ncb2157 Received 05 May 2010 Accepted 06 December 2010 Published online 16 January 2011
摘要：The biogenesis of the many functional compartments contained in the mammalian cell nucleus is poorly understood. More specifically, little is known regarding the initial nucleation step required for nuclear body formation. Here we show that RNA can function as a structural element and a nucleatorof nuclear bodies. We find that several types of coding and noncodingRNAs are sufficient to de novoassemble, and are physiologically enriched in, histonelocus bodies (with associated Cajalbodies), nuclear speckles, paraspecklesand nuclear stress bodies. Formation of nuclear bodies occurs through recruitment and accumulation of proteins resident in the nuclear bodies by nucleating RNA. These results demonstrate that transcription is a driving force in nuclear body formation and RNA transcripts can function as a scaffold in the formation of major nuclear bodies. Together, these data suggest that RNA-primed biogenesis of nuclear bodies is a general principle of nuclear organization.
1.哺乳动物细胞核包含的功能组分的生物起源并不清楚。更具体的说，关于核体形成所需的起始成核步骤知之甚少。这里，我们展示了RNA可以行使结构元件的功能并且作为核体的成核剂。
2.我们发现几类编码和非编码RNA就足以从头组装组蛋白体（与Cajal氏体相关）、核斑、旁斑和压力体（nSB），并且在生理状况下它们中富集。核体的形成通过成核RNA募集并使蛋白在核体中积累。
3.这些结果阐释转录是核体形成的驱动力且RNA转录物能行使主要核体形成支架的功能。总而言之，这些数据暗示一个细胞核组织的一般原则：以RNA为本的核体的生物起源。

[ Last edited by silicare on 2011-4-1 at 18:04 ]

回复此楼