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974790421(金币+10, 翻译EPI+1): 2011-03-28 17:11:00
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Modified beta cyclodextrins (beta CD) substrate molecule with model the coordination effect of general relatively weak, even in its edge arm, introducing some function is difficult to significantly improve the simple modified its molecular bonding ability, this is largely limiting cyclodextrins in simulation of enzyme and identify the application of substrate, etc. But if the two cyclodextrins unit through proper groups.important up, can get with dual scanty water binding and multiple identification function of the bridge, because even 2-ring dextrin binding sites, and can increase by adjusting the connection to achieve appropriate geometry groups in the match, the two adjacent cyclodextrins cavity can collaborative participation on the shape and size of the object for molecule bag knot, expand molecular bonding ability, give higher the coordination stable constants, this characteristic that might in the substrates and antigen enzyme. Strong bonding. Antibodies interaction get important application simulation study. |
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