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金黄益胆颗粒对原发性胆管结石病人术后血浆胃肠激素水平的影响 原发性胆管结石是胆道系统的常见病和多发病，目前西医治疗胆管结石的效果尚不满意，表现为碎石后、手术取石后，结石残余率、复发率和再手术率较高，西药溶石效果又不理想、且适应症受到限制，毒副作用也较大。因此，借助现代中医药发展的新成果，探讨胆管结石形成的原因和预防手术后结石复发，是近几年来人们关注的课题。 目的 近些年来，人们通过对胆管结石成因的研究，发现胃肠道、胆道动力异常在胆管结石中扮演者重要角色，胃肠道、胆道动力受胃肠激素的调节，胃肠激素中某个或某几个重要激素发生变化，均可导致胃肠道，胆道功能紊乱，胆汁分泌异常，可出现成石性胆汁，导致胆泥析出，结石形成。随着现代中医药的发展，发现某些中药具有调节胃肠激素的作用。根据这一启发，给原发性胆总管结石术后患者，服用金黄益胆颗粒，通过放射免疫检测分析法(radioimmunoassay, RIA )检测血浆胃动素、生长抑素 、P物质水平，借此探讨金黄益胆颗粒对原发性胆总管结石病人术后结石复发的预防机理。 材料与方法 一、材料 (一)主要仪器和设备：SHINKO一SH一210R电子分析天平； GC-2016r放射免疫计数器； LDR4—8．4C医用离心机 ； SANYO一70℃超低温冰箱。 (二)主要试剂：抑肤酶(4万kiu/ML,2ML/瓶) ； 7.5% EDTA一2Na（2ML/瓶)； 胃动素放射免疫检测试剂盒 ；.P物质放射免疫检测试剂盒。 二、实验方法 (一)研究对象 病例样本主要为开滦医院2008年5 月——2009年 5月间入院的原发性或复发性胆管结石患者66例；正常对照组为身体健康的医护人员和病人家属10人。以上受试者，近期内均未服用影响胃肠道、胆道动力的药物。胆管结石病人住院后，根据结石部位，选择的合适的手术方式，所有患者均术中采用胆道镜取石。在这些病历中均排除了同时伴胆囊结石的患者,急性梗阻性化脓性胆管炎患者，腹部合并其他胃肠道疾病患者， 糖尿病、脂肪肝、肝硬化、乙型肝炎及高脂血症患者，对药物过敏不能耐受的患者，行单纯胆肠吻合术的患者，妊娠或准备妊娠妇女，哺乳期妇女等。所有患者随机分为：服药组（服用金黄益胆颗粒组）、对照组（自然恢复组），正常组（正常健康者），各组中年龄及性别比较见下表 |
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sltmac(金币+30): 2011-04-25 12:50:40
sltmac(金币+30, 翻译EPI+1): 欢迎常来~~ 2011-04-25 12:50:49
sltmac(金币+30): 2011-04-25 12:50:40
sltmac(金币+30, 翻译EPI+1): 欢迎常来~~ 2011-04-25 12:50:49
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Jin Huangyi particles of primary bile duct stones after the impact of plasma levels of gastrointestinal hormones Primary biliary duct stones are a common and frequently-occurring disease, the current effects of Western medicine treatment of bile duct stones is still not satisfied with the performance of the stone after stone after surgery, residual stone rate, relapse rate and higher rate of re-operation, Western RONGSHI effect is not satisfactory, and the indication is restricted, toxic side effects as well. Therefore, the development of Chinese medicine with modern new achievements in the formation of bile duct causes and prevention of stone recurrence after surgery, the subject of attention in recent years. Objective In recent years, people on the causes of bile duct stones and found that the gastrointestinal tract, biliary motility disorders actor in the important role of bile duct stones, gastrointestinal tract, biliary dynamic regulation by gastrointestinal hormones, gastrointestinal hormones in one or changes to a number of important hormones, can lead to gastrointestinal tract, biliary disorders, abnormal secretion of bile, bile stone formation can occur, leading to precipitation of biliary sludge, gallstone formation. With the development of modern Chinese medicine, traditional Chinese medicine have found that some of the role of regulating gastrointestinal hormones. Under this inspiration, to patients with primary common bile duct stones after taking Jin Huangyi bile particles detected by radioimmunoassay method (radioimmunoassay, RIA) measurement of plasma motilin, somatostatin, P material level, to explore Jin Huangyi primary bile duct stones particles on stone recurrence after surgery prevention mechanism. Materials and methods First, material (A) of the main instruments and equipment: SHINKO a SH a 210R electronic balance; GC-2016r RIA counter; LDR4-8.4C Centrifuge; SANYO ultra-low temperature freezer for a 70 ℃. (B) of the main reagents: suppression skin enzyme (40 000 kiu / ML, 2ML / bottle); 7.5% EDTA a 2Na (2ML / bottle); motilin radioimmunoassay kit;. P substance radioimmunoassay kit. Second, the experimental method (A) of the study Kailuan case samples mainly hospital in May 2008 - May 2009 between the primary or recurrent hospitalization in patients with 66 cases of bile duct stones; normal healthy control group for the families of 10 health care workers and patients. These subjects were not taking near-term impact of the gastrointestinal tract, biliary power of the drug. Bile duct stones after hospitalization, according to stone location, select the appropriate surgical approach, surgery in all patients with biliary stone mirror. In these records are excluded in both patients with gallbladder stones, acute obstructive suppurative cholangitis in patients with abdominal combined with other gastrointestinal diseases, diabetes, fatty liver, cirrhosis, hepatitis B and patients with hyperlipidemia, can not tolerate the drug allergy in patients with simple biliary-enteric anastomosis in patients with pregnancy or for pregnant women and lactating women. All patients were randomly divided into: drug group (taking Jinhuang Yi bile particle group), the control group (natural recovery group), normal group (normal healthy), age and sex of each group comparison table below |
2楼2011-03-22 14:47:57
