| ²é¿´: 405 | »Ø¸´: 2 | |||
| ±¾Ìû²úÉú 1 ¸ö ·ÒëEPI £¬µã»÷ÕâÀï½øÐв鿴 | |||
[½»Á÷]
Çó·Òë³ÉÖÐÎÄ
|
|||
|
To date, different mutations have been reported that result in a complete deficiency, including: two deletions (295¨C298delTCAT and 1897delC), one splice-site mutation (IVS14+IG>A), four missense mutations (85T>C, 703C>T, 2657G>A, and 2983 G>T), a deletion of two nucleotides (1039¨C1040delTG), and the point mutations P86L, S201R, S492L, D949V and H978R [13]. The 85T>C mutation might be a common polymorphism, although functional analysis of a recombinantly expressed human protein carrying the 85T>C mutation showed no significant residual mutant enzyme activity [10,14]. An in-depth discussion of the clinical import of DPD can be found in a number of review articles, and two examples are provided in Refs. [37,38], which discuss the role of DPD in cancer therapy with 5FU |
» ²ÂÄãϲ»¶
»¯¹¤Ñ§Ë¶294·Ö£¬Çóµ¼Ê¦ÊÕÁô
ÒѾÓÐ29È˻ظ´
Çóµ÷¼Á
ÒѾÓÐ10È˻ظ´
¿¼ÑÐÇóµ÷¼Á
ÒѾÓÐ13È˻ظ´
Çóµ÷¼Á
ÒѾÓÐ3È˻ظ´
È˹¤ÖÇÄÜ320µ÷¼Á08¹¤À໹Óлú»áÂð
ÒѾÓÐ17È˻ظ´
¿¼ÑÐÓ¢Ò»ÊýÒ»338·Ö
ÒѾÓÐ10È˻ظ´
ÇóÖúµ÷¼Á£¬¿çµ÷
ÒѾÓÐ15È˻ظ´
085600²ÄÁÏÓ뻯¹¤329·ÖÇóµ÷¼Á
ÒѾÓÐ20È˻ظ´
085600²ÄÁÏÓ뻯¹¤349·ÖÇóµ÷¼Á
ÒѾÓÐ15È˻ظ´
Çóµ÷¼Á
ÒѾÓÐ13È˻ظ´
» ÇÀ½ð±ÒÀ²£¡»ØÌû¾Í¿ÉÒԵõ½:
ÐÂ¼ÓÆÂ¹úÁ¢´óѧÕÅÑô½ÌÊÚ¿ÎÌâ×éÕÐÆ¸²©Ê¿ºó£¨AIÓëÉúÎïҽѧ½»²æ·½Ïò£©
+2/236
ר˶£¨×ÊÔ´Óë»·¾³¡¢ÍÁľˮÀû£©£¬½ÓÊÕ¿çרҵ£¬¹¤Ñ§¡¢Àíѧ¶¼ÐУ¡
+1/88
´óÍåÇø´óѧÀîºì¸ýÓëÖйú¿ÆÑ§¼¼Êõ´óѧÍõÁø½ÌÊÚÁªºÏÕÐÊÕ²©Ê¿ºó
+1/87
³¤½´óѧ»¯¹¤Ñ§Ôº¡¾0857×ÊÔ´Óë»·¾³¡¿ÕÐÀíѧ¡¢¹¤Ñ§µ÷¼ÁÉú£¡
+1/87
ÉòÑô¹¤Òµ´óѧ»·¾³Ó뻯ѧ¹¤³ÌѧԺ »·¾³¿ÆÑ§Ó빤³Ì£¨083000£©Ñ§Ë¶ ÈÔÓе÷¼ÁÃû¶î£¡
+1/87
Î÷°²½»Í¨´óѧÉÂÎ÷Ê¡¿Æ¼¼´´ÐÂÍŶӳ£ÄêÕÐÆ¸±£ËÍÉúºÍ¿¼ÑÐÉú£¬Ã¿Äê2-4¸öÃû¶î
+1/40
±±¾©Àí¹¤´óѧ£¨Ö麣£©ÕÐÊÕÈ˹¤ÖÇÄÜ·½Ïò26¼¶²©Ê¿
+1/21
ºþÄÏÀí¹¤´óѧ»¯Ñ§»¯¹¤Ñ§ÔºµÄ»¯Ñ§ºÍ»¯Ñ§¹¤³ÌÓë¼¼Êõרҵµ÷¼Á
+1/11
ÁÉÄþ¹¤Òµ´óѧÍÁľ¹¤³Ì£¨081400£©×¨Òµµ÷¼ÁÓÐÃû¶î
+1/10
¸´ÊÔµ÷¼Á-ÕÐÊÕµ÷¼ÁÉú£¨Ò»Ö¾Ô¸07¿ªÍ·×¨Òµ£©£¬º£ÑóÉúÎïרҵ4¸öÃû¶î
+1/10
ÖпÆÔºÀí»¯ËùÈÈÉùÈÈ»úÍŶÓÕÐÆ¸µçÆø¹¤³Ìרҵ(µç»ú·½Ïò)²©Ê¿ºó/ÌØ±ðÑо¿ÖúÀí
+1/9
ÖØÇìÈýÏ¿¿Æ¼¼´óѧÎïÀíµç×Óѧ¡¢³¡²¨×¨Òµ½ÓÊÕµ÷¼Á£¬¿¼Êý¶þ¿Éµ÷£¬ÏµÍ³¿ªÖÁ4ÔÂ10ÈÕ
+1/9
Öйú¿ÆÑ§¼¼Êõ´óѧËÕÖݸߵÈÑо¿Ôº·ï½¨¸Ú¿ÎÌâ×é³ÏÕв©Ê¿ºó
+1/9
Ê¡ÖØµãʵÑéÊÒÕÐÊÕ07רҵµ÷¼ÁÉú£¬º£ÑóÉúÎïרҵÃû¶î³ä×ã
+1/9
Öйú¿ÆÑ§¼¼Êõ´óѧ-°²»Õ´óѧ¸ßнÁªºÏÕÐÆ¸²©Ê¿ºó/¸±Ñо¿Ô±
+1/7
ÆëÆë¹þ¶û´óѧÀîÀò¿ÎÌâ×é³ÏÕÐ2026¼¶¿¼Ñе÷¼ÁÉú£¨Ñ§Ë¶ºÍר˶£©
+1/6
¸£½¨Àí¹¤´óѧѧ˶רҵ´úÂë08¿ªÍ·»¹Óе÷¼ÁÃû¶î
+1/5
½Î÷Ë®ÀûµçÁ¦´óѧÊÐÕþ¹¤³Ì½ÓÊܵ÷¼Á
+1/4
¸£½¨Àí¹¤´óѧ²ÄÁÏѧԺÕÐÊÕרҵ´úÂë08¿ªÍ·Ñ§ÊõÐÍ˶ʿÑо¿Éú
+1/2
½Î÷¿Æ¼¼Ê¦·¶´óѧÉêÁÁ×éÕÐÑо¿Éú£¨¸ß·Ö×Ó»¯Ñ§×¨Òµ£©
+1/2
µØÍ¼ÎÏÅ£
Òø³æ (СÓÐÃûÆø)
- ·ÒëEPI: 9
- Ó¦Öú: 0 (Ó×¶ùÔ°)
- ½ð±Ò: 339.4
- Ìû×Ó: 71
- ÔÚÏß: 16.5Сʱ
- ³æºÅ: 804596
ЦÊÀ¿ñÁú(½ð±Ò+25, ·ÒëEPI+1): ллÄã 2011-03-11 20:27:42
|
ÄúÊDz»ÊǰÑһƪDPDµÄ×ÛÊöÒ»µãµãÌùѽ¡£ ĿǰÒѱ¨µÀÓжà¸öÍ»±äµ¼ÖÂÍêÈ«¹¦ÄÜȱʧ£¬ÕâЩͻ±äÓУºÁ½¸öȱʧͻ±ä£¨295¨C298delTCAT and 1897delC£©£¬Ò»¸ö¼ô½ÓλµãÍ»±ä(IVS14+IG>A)£¬4¸ö´íÒåÍ»±ä(85T>C, 703C>T, 2657G>A, and 2983 G>T)£¬Ò»¸öÁ½¸öºËÜÕËáµÄȱʧͻ±ä(1039¨C1040delTG)ºÍ¼¸¸öµãÍ»±äP86L, S201R, S492L, D949V and H978R¡£85T>CÍ»±ä¿ÉÄÜÊÇÒ»¸ö±È½ÏÆÕ±éµÄ¶à̬ÐÔ£¬µ«Ð¯´ø85T>CÍ»±äµÄÖØ×éÈËDPDµ°°×²¢Ã»ÓÐÃ÷ÏÔµÄÍ»±äøµÄ»îÐÔ²ÐÓà¡£´óÁ¿×ÛÊöÒѾÉîÈëÌÖÂÛÁËDPDµÄÖØÒªÁÙ´²×÷Óã¬ÎÄÏ×37£¬38ÖоÍÓÐÁ½¸öÀý×Ó£¬ÕâÁ½Æª×ÛÊöÌÖÂÛÁËDPDÔÚ5FUÖÎÁư©Ö¢ÖеÄ×÷Óᣠ|
2Â¥2011-03-11 10:50:33
3Â¥2011-03-11 20:40:20














»Ø¸´´ËÂ¥