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Campillos et al. (2008) was the use of similarities in the sideeffects of known drugs to predict new drug-target interactions, some of which were verified by in vitro binding assays. The limitation of this approach is that it only applies to known side-effects of known drugs, thus limiting the ability of the method to perform high-throughput screening of potential interactions between new molecules and proteins. |
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4楼2011-03-04 11:12:58
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
pku123(金币+1, 翻译EPI+1): 2011-03-04 09:37:38
pku123(金币+1): 2011-03-05 07:32:19
ringzhu(金币+16): 不解释~~ 2011-03-15 10:23:03
pku123(金币+1, 翻译EPI+1): 2011-03-04 09:37:38
pku123(金币+1): 2011-03-05 07:32:19
ringzhu(金币+16): 不解释~~ 2011-03-15 10:23:03
|
Campillos et al. (2008) was the use of similarities in the side effects of known drugs to predict new drug-target interactions, some of which were verified by in vitro binding assays. The limitation of this approach is that it only applies to known side-effects of known drugs, thus limiting the ability of the method to perform high-throughput screening of potential interactions between new molecules and proteins. Campillos 等(2008)用一只药物的副作用的相似性预测新药和靶标间的相互作用，其中一些相互作用由体内结合使用确证。这种方法的局限是它只应用了已知药物的已知副作用，因此限制了其在新分子和蛋白质之间潜在相互作用的高通量筛选中的应用。 |
2楼2011-03-04 09:37:04
3楼2011-03-04 09:38:04
