| 查看: 677 | 回复: 4 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
leiking木虫 (正式写手)
中医药
|
[交流]
【Share】GENOME-ANNIVERSARY ~~GENOMICS AND CLINICAL RELEVANCE
|
||
|
When I interact with physicians, I realize that the clinical questions they think are most relevant are more sophisticated than those posed by the first wave of whole-genome studies. When I ask questions that are clinically relevant, they are not what I asked myself in 2001, when the landmark human genome-sequencing papers were published. At that time, my thinking process was DNA-driven: What is functional? What is normal genome variation? What amazes me in retrospect is that I did not appreciate the fact genomic information and technologies would grow more than a millionfold in the following decade and, in a way, leap-frog other critical initiatives in health research. Now, clinicians are more and more concerned by overdetection, overdiagnosis, and overtreatment of diseases, as a result of sensitive tests ( e.g.,prostate-specific antigen for prostate cancer). Whether the disease involves cancer, metabolism, inflammation, or neurodegeneration, it becomes apparent that we have a limited knowledge of disease processes over time and, consequently, limited knowledge of when to intervene and to what degree. In some patients, this lead to unnecessary complications, whereas in others, the failure to act early is irreparable. If I could move the clock back to 2001 and change course, I would invest significantly more in developing large clinical resources with detailed clinical histories, deep phenotyping, and longitudinal follow-up in order to better understand outcomes and treatment responses. If genomics was now being integrated with such resources, we would be closer to achieving a form of personalized medicine that clinicians would be eager to adopt. |
回复此楼» 猜你喜欢
求调剂
已经有3人回复
-
材料与化工调剂
已经有4人回复
-
本9一志愿2 0854低分专硕286求调剂
已经有10人回复
-
298求调剂
已经有9人回复
-
材料专业344求调剂
已经有12人回复
-
282，电气工程专业，求调剂，不挑专业
已经有6人回复
-
301求调剂
已经有3人回复
-
一志愿211，化学学硕，310分，本科重点双非，求调剂
已经有28人回复
-
材料085601调剂
已经有17人回复
-
一志愿0703化学招61最终排名62化学求调剂
已经有23人回复
 |
5楼2011-02-18 13:16:23
