| 查看: 779 | 回复: 4 | |||
leiking木虫 (正式写手)
中医药
|
[交流]
【Share】GENOME-ANNIVERSARY ~~GENOMICS AND CLINICAL RELEVANCE
|
|
When I interact with physicians, I realize that the clinical questions they think are most relevant are more sophisticated than those posed by the first wave of whole-genome studies. When I ask questions that are clinically relevant, they are not what I asked myself in 2001, when the landmark human genome-sequencing papers were published. At that time, my thinking process was DNA-driven: What is functional? What is normal genome variation? What amazes me in retrospect is that I did not appreciate the fact genomic information and technologies would grow more than a millionfold in the following decade and, in a way, leap-frog other critical initiatives in health research. Now, clinicians are more and more concerned by overdetection, overdiagnosis, and overtreatment of diseases, as a result of sensitive tests ( e.g.,prostate-specific antigen for prostate cancer). Whether the disease involves cancer, metabolism, inflammation, or neurodegeneration, it becomes apparent that we have a limited knowledge of disease processes over time and, consequently, limited knowledge of when to intervene and to what degree. In some patients, this lead to unnecessary complications, whereas in others, the failure to act early is irreparable. If I could move the clock back to 2001 and change course, I would invest significantly more in developing large clinical resources with detailed clinical histories, deep phenotyping, and longitudinal follow-up in order to better understand outcomes and treatment responses. If genomics was now being integrated with such resources, we would be closer to achieving a form of personalized medicine that clinicians would be eager to adopt. |
回复此楼» 猜你喜欢
面上提前没消息，有中的吗
已经有12人回复
-
售一区SCI文章T0P，我:8O.551.O54,科目全,可十急
已经有8人回复
-
售SCI一区T0P文章，我:8.O.55.1.O.5.4,科目全,可+急
已经有8人回复
-
售SCI一区文章，我:8O5.5.1.O5.4,科目全,可伽急
已经有4人回复
-
售SCI一区T0P文章，我:8.O.55.1.O.54,科目齐全,可+急
已经有6人回复
-
售一区SCI文章T0P，我:8O.551.O54,科目全,可十急
已经有8人回复
-
售SCI一区文章，我:8O5.5.1.O5.4,科目全,可伽急
已经有9人回复
-
售SCI一区文章，我:8O5.5.1.O5.4,科目全,可伽急
已经有8人回复
-
售SCI一区T0P文章，我:8O.55.1.O.5.4,科目齐全,可+急
已经有9人回复
-
售SCI一区文章，我:8.O.551.O.5.4,科目全,可伽急
已经有10人回复
★
小木虫(沙发+1，金币+0.5):恭喜抢个沙发，再给个红包
小木虫(沙发+1，金币+0.5):恭喜抢个沙发，再给个红包
 |
2楼2011-02-18 09:45:16
★
小木虫(金币+0.2):抢了个小板凳，给个红包
小木虫(金币+0.2):抢了个小板凳，给个红包
 |
3楼2011-02-18 09:46:12
 |
4楼2011-02-18 10:40:38
 |
5楼2011-02-18 13:16:23
50