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| The antioxidant property of jionoside D, isolated from Clerodendron trichotomum (Verbenaceae), was investigated. This compound showed scavenging activity of intracellular reactive oxygen species and of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as lipid peroxidation inhibitory activity. This radical scavenging activity of jionoside D protected the cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed H2O2. Furthermore, jionoside D reduced the apoptotic cells induced by H2O2, as demonstrated by the decreased number of sub G1 hypo-diploid cells and apoptotic body formation. However, it increased the activities of cellular antioxidant enzymes, superoxide dismutase and catalase. Taken together, these findings suggest that jionoside D, isolated from C. trichotomum, exhibits antioxidant properties. |
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cxxmf(金币+10, 翻译EPI+1): 2011-02-14 09:09:41
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从Clerodendron trichotomum (Verbenaceae), 中提取的jionoside D ，其抗氧化功能得到了研究。该化合物表现出净化细胞内活性氧与DPPH 自由基的活性，同时，也有抑制脂质过氧化作用的活性。jionoside D 的自由基净化功能使中国仓鼠肺纤维原细胞(V79-4)不接触到H2O2。此外，jionoside D减少了H2O2导致的细胞凋亡，其依据是G1亚二倍体细胞和凋亡小体形成数量的减少。然而，其增强了细胞抗氧化酶，超氧化物歧化酶，过氧化氢酶的活性。综上，这些发现说明从C. trichotomum 中提取的jionoside D 具有抗氧化功能。 希望能楼主有帮助！ |
2楼2011-02-13 20:56:22
