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yinhuanshun

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[交流] 生物方面一小段话翻译

Not only the spectrum of miRNAs expressed in malignant cells is significantly different from that of normal counterpart cells but also miRNA expression profiles better classify poorly differentiated tumors as compared with the mRNA (EST)-based classifier. Commonly deregulated miRNAs in different types of solid cancers predict their involvement in fundamental pathways and their interaction with important cancer-specific PCGs. Furthermore,such abnormal expression was found not only in malignant cells but also in premalignant stages, such as colon adenomas where miR-143 and miR-145 expression is reduced or in pituitary adenomas, a type of benign tumors displaying deletions at 13q14.3 and reduced expression of miR-16-1 and miR-15a.

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yinhuanshun(金币+20, 翻译EPI+1): 谢谢 2011-01-18 18:20:21
这段话的意思是:

miRNA在肿瘤和正常组织的表达谱区别很明显。而且和EST(mRNA)相比,miRNA也能很好的区分正常组织和未分化的肿瘤,所以miRNA比est要好
表达失控的miRNA会影响细胞传导通路,这种情况不仅仅出现在恶性肿瘤中,也出现在癌变前期和良性肿瘤中,比如结肠癌的miR-143 , miR-145 和垂体瘤的 miR-16-1 和 miR-15a
2楼2011-01-18 16:50:05
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