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Not only the spectrum of miRNAs expressed in malignant cells is significantly different from that of normal counterpart cells but also miRNA expression profiles better classify poorly differentiated tumors as compared with the mRNA (EST)-based classifier. Commonly deregulated miRNAs in different types of solid cancers predict their involvement in fundamental pathways and their interaction with important cancer-specific PCGs. Furthermore,such abnormal expression was found not only in malignant cells but also in premalignant stages, such as colon adenomas where miR-143 and miR-145 expression is reduced or in pituitary adenomas, a type of benign tumors displaying deletions at 13q14.3 and reduced expression of miR-16-1 and miR-15a. 谢谢！！！ |
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2楼2011-01-18 16:50:05
