| 查看: 898 | 回复: 4 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
[交流]
帮忙翻译一下文摘
|
|||
|
Hepatocellular carcinoma (HCC) is a highly malignant tumor, and chronic infection with hepatitis B virus is one of its major risk factors. To identify the proteins involved in HCC carcinogenesis, we used two-dimensional fluorescence DIGE to study the differentially expressed proteins in tumor and adjacent nontumor tissue samples. Samples from 12 hepatitis B virus-associated HCC patients were analyzed. A total of 61 spots were significantly up-regulated (ratio > 2, p < 0.01) in tumor samples, whereas 158 spots were down-regulated (ratio < _2, p < 0.01). Seventyone gene products were identified among these spots. Members of the heat shock protein 70 and 90 families were simultaneously up-regulated, whereas metabolismassociated proteins were decreased in HCC samples. The down-regulation of mitochondrial and peroxisomal proteins in these results suggested loss of special organelle functions during HCC carcinogenesis. Four metabolic enzymes involved in the methylation cycle in the liver were down-regulated in HCC tissues, indicating S-adenosylmethionine deficiency in HCC. Two gene products, glyceraldehyde-3-phosphate dehydrogenase and formimidoyltransferase-cyclodeaminase, were identified from inversely altered spots, suggesting that different isoforms or post-translational modifications of these two proteins might play different roles in HCC. For the first time, the overexpression of Hcp70/Hsp90-organizing protein and heterogeneous nuclear ribonucleoproteins C1/C2 in HCC tissues was confirmed by Western blot and then by immunohistochemistry staining in 70 HCC samples, suggesting their potential as protein tumor markers. In summary, we profiled proteome alterations in HCC tissues, and these results may provide useful insights for understanding the mechanism involved in the process ofHCC carcinogenesis. Molecular & Cellular Proteomics 6:1798–1808, 2007. |
回复此楼» 猜你喜欢
化学调剂
已经有5人回复
-
考研调剂
已经有4人回复
-
求调剂推荐 材料 304
已经有14人回复
-
【求调剂】085601材料工程专硕 | 总分272 |
已经有3人回复
-
学硕274求调剂
已经有4人回复
-
291求调剂
已经有18人回复
-
275求调剂
已经有7人回复
-
266求调剂
已经有11人回复
-
265求调剂
已经有5人回复
-
求调剂
已经有7人回复
» 抢金币啦！回帖就可以得到:
-
中国散裂中子源诚聘“AI材料计算”方向博士后/职工
+1/393
-
山东建筑大学材料类研究生招生调剂
+3/200
-
老虫子的注册小木虫18周年大礼包
+5/150
-
南方医科大学中药学院 调剂硕士生一名 中药学专业
+1/84
-
沈阳工业大学-环境电化学技术研究团队-招收硕士研究生
+3/60
-
重庆交通大学院士团队招收材料、能源动力专业硕士研究生
+2/52
-
长江师范学院 材料与化工专业 金磊老师课题组招收调剂学生
+1/43
-
【林业专业硕士调剂1名】中国林业科学研究院
+1/37
-
环境化学、地学、环境毒理方向，擅长污染物迁移转化降解、分析检测、计算模拟者优先
+1/34
-
【分享】招收08工学硕士（要求过国家线）
+1/34
-
济南大学水利与环境学院赵艳侠教授简介
+1/29
-
长安大学智能爆破课题组招收2026级博士和硕士研究生
+1/25
-
【2026调剂】南方科技大学-深圳理工大学-中科院 联培086000免疫方向(26.9入学)
+1/11
-
北京某研究院结构生物学相关专业接收调剂研究生
+1/10
-
欢迎调剂报考
+1/6
-
武汉纺织大学招收硕士研究生调剂 （社牛最好）
+1/5
-
宁波东方理工大学余鹏课题组2026年上海交大联培博士生、博士后、科研助理招聘
+1/3
-
英国剑桥好房出租
+1/3
-
湘潭大学教师招聘
+1/1
-
香港大学 化学系 博后招聘
+1/1
4楼2010-12-19 20:53:45
3楼2010-12-19 20:00:03
5楼2010-12-23 16:42:12
简单回复
cfm8772楼
2010-12-19 08:06
