| 查看: 976 | 回复: 4 | |||
[交流]
帮忙翻译一下文摘
|
|||
|
Hepatocellular carcinoma (HCC) is a highly malignant tumor, and chronic infection with hepatitis B virus is one of its major risk factors. To identify the proteins involved in HCC carcinogenesis, we used two-dimensional fluorescence DIGE to study the differentially expressed proteins in tumor and adjacent nontumor tissue samples. Samples from 12 hepatitis B virus-associated HCC patients were analyzed. A total of 61 spots were significantly up-regulated (ratio > 2, p < 0.01) in tumor samples, whereas 158 spots were down-regulated (ratio < _2, p < 0.01). Seventyone gene products were identified among these spots. Members of the heat shock protein 70 and 90 families were simultaneously up-regulated, whereas metabolismassociated proteins were decreased in HCC samples. The down-regulation of mitochondrial and peroxisomal proteins in these results suggested loss of special organelle functions during HCC carcinogenesis. Four metabolic enzymes involved in the methylation cycle in the liver were down-regulated in HCC tissues, indicating S-adenosylmethionine deficiency in HCC. Two gene products, glyceraldehyde-3-phosphate dehydrogenase and formimidoyltransferase-cyclodeaminase, were identified from inversely altered spots, suggesting that different isoforms or post-translational modifications of these two proteins might play different roles in HCC. For the first time, the overexpression of Hcp70/Hsp90-organizing protein and heterogeneous nuclear ribonucleoproteins C1/C2 in HCC tissues was confirmed by Western blot and then by immunohistochemistry staining in 70 HCC samples, suggesting their potential as protein tumor markers. In summary, we profiled proteome alterations in HCC tissues, and these results may provide useful insights for understanding the mechanism involved in the process ofHCC carcinogenesis. Molecular & Cellular Proteomics 6:1798–1808, 2007. |
» 猜你喜欢
filecode=后面第一个是大写字母
已经有11人回复
为什么余额宝的年化利率越来越低?主要原因有哪些?
已经有4人回复
今天放榜吗?
已经有13人回复
filecode,4个jtjc了
已经有9人回复
今天基金会出结果吗?20260819
已经有8人回复
欢迎发来filecode的Mz6后的代码验证其规律
已经有115人回复
2027广东省杰青
已经有10人回复
朋友圈看到的
已经有8人回复
时间戳变了,能看出什么问题?
已经有14人回复
咱们一起用铁证分析2026国家社科基金中标与否
已经有30人回复
» 抢金币啦!回帖就可以得到:
每年这时候我都再仔细读一遍《范进中举》
+1/575
散尽家财,祈求中标。
+5/290
一点琐碎的家务事,却非常困扰我,让我内耗
+2/104
山东征女友,坐标济南
+1/91
哈尔滨工业大学(校本部)电子与信息工程学院2027级博士招生
+1/80
上海交通大学张航课题组招聘博士后(电化学能量存储与转换)
+1/79
散金币祈福
+1/68
上海交通大学张航课题组招聘博士后(电化学储能)
+1/45
武汉,诚征男友,不异地,年龄大了
+1/40
2027环境工程博士申请
+1/9
老虫友
+1/7
中国科学院生态环境研究中心环境工程相关方向招收保送硕士和联合培养博士和硕士研究生
+1/4
27推免-广州医科大学封红亮教授招收精神医学应用心理学推免生
+1/3
北京理工大学-集成电路与电子学院杰青团队-招博士后
+1/3
出全新蔡司 Plan?APOCHROMAT 20×/0.8 平场复消色差物镜
+1/3
南京医科大学-冯璋课题组-招收2027级生化与分子生物学专业博士和硕士研究生
+1/3
清华大学环境课题组招聘环境工作专业客座生研究生2-3名(应用导向)
+1/2
河海大学海洋环境污染与生态毒理学研究组招收2027级硕士生 及博士研究生
+1/2
南京工业大学段金贵团队:分子纳米线组装策略,攻克高温下C2H2/CO2分离难题
+1/1
【产品测评分享】体外转录产量不理想、dsRNA 副产物高?T7 RNA 聚合酶实测体验
+1/1
3楼2010-12-19 20:00:03
4楼2010-12-19 20:53:45
5楼2010-12-23 16:42:12
简单回复
cfm8772楼
2010-12-19 08:06













回复此楼