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wuhuajiang

捐助贵宾 (著名写手)

单身家族之lucky

[交流] [急]麻烦帮我查一个反应，用CA，BEILSTAIN

请大家帮忙查一反应
附件见http://free.ys168.com/?organic
谢谢
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1楼 2006-06-21 16:18:36
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weixiaobao-000

至尊木虫 (著名写手)

探险者

SOS!!

那位大哥有下面这种物质的合成方法啊?帮忙用ＣＡ查一下吧！
我用CHEMDRAW命名的：penta-1,4-dien-3-one
我也不知道它的俗名是啥,最好能提供几篇相关文献吧!
请赐教啊!!
多谢了!
详细请见http://muchong.com/bbs/viewthread.php?tid=292786&fpage=1
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真爱如同关节炎，只有在你初次尝到它的滋味时，你才会相信它的存在！
10楼2006-08-15 16:54:37
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peak21st

木虫 (著名写手)

古道西风
★
zhaoyusnow(金币+1):感谢参与，欢迎常来
Potassium Alkenyl- and Aryltrifluoroborates: Stable and Efficient Agents for Rhodium-Catalyzed Addition to Aldehydes and Enones.     Batey, Robert A.; Thadani, Avinash N.; Smil, David V.    Department of Chemistry Lash Miller Chemical Laboratories,  University of Toronto,  Toronto,  ON,  Can.    Organic Letters  (1999),  1(10),  1683-1686.

t-Bu-Amphos-RhCl3.3H2O. A highly recyclable catalyst system for the cross-coupling of aldehydes and aryl- and alkenylboronic acids in aqueous solvents.     Huang, Rongcai; Shaughnessy, Kevin H.    Department of Chemistry and the Center for Green Manufacturing,  The University of Alabama,  Tuscaloosa,  AL,  USA.    Chemical Communications (Cambridge, United Kingdom)  (2005),   (35),  4484-4486.

[ Last edited by peak21st on 2006-6-21 at 17:18 ]
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咬定青山不放松，立根原在破岩中。千磨万击还坚劲，任尔东西南北风。
3楼2006-06-21 16:37:29
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wuhuajiang

捐助贵宾 (著名写手)

单身家族之lucky
另外帮忙查查
4-oxo-4-p-tolylbutanoic acid
呵呵
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4楼2006-06-21 16:41:52
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peak21st

木虫 (著名写手)

古道西风
★ ★ ★ ★ ★ ★ ★ ★ ★ ★
wuhuajiang(金币+10):非常感谢你的帮助，希望以后还可以呵呵
呵呵，别客气, 第二个的合成



Bibliographic Information

Highly chemoselective hydrogenation method using novel finely dispersed palladium catalyst on silk-fibroin: its preparation and activity.      Ikawa, Takashi; Sajiki, Hironao; Hirota, Kosaku.    Laboratory of Medicinal Chemistry,  Gifu Pharmaceutical University,  5-6-1 Mitahora-higashi, Gifu,  Japan.    Tetrahedron  (2005),  61(8),  2217-2231.  Publisher: Elsevier B.V.,  CODEN: TETRAB  ISSN: 0040-4020.  Journal  written in English.    CAN 142:355011    AN 2005:125076    CAPLUS   (Copyright (C) 2006 ACS on SciFinder (R))   

Abstract

A palladium-fibroin complex (Pd/Fib) was prepd. by soaking silk-fibroin in MeOH soln. of Pd(OAc)2 for 2 days (under Ar atm.)-4 days (under air).  Pd(OAc)2 was gradually absorbed by fibroin and the rapid redn. of fibroin conjugated Pd(OAc)2 proceeded with MeOH as a reductant at room temp. to be the Pd(0) complex.  Pd/Fib catalyzed chemoselective hydrogenation of acetylenes, olefins and azides in the presence of arom. ketones and aldehydes, halides, N-Cbz protective groups and benzyl esters which are readily hydrogenated using Pd/C or Pd/C(en) as a catalyst.

Bibliographic Information

Synthesis of new 2-arylidene-4-(4-methylphenyl)but-3-en-4-olides and their pyrrolone derivatives.      Husain, Asif; Hasan, S. M.; Lal, Sukhbir; Alam, M. Mumtaz.    Department of Pharmaceutical Chemistry, Faculty of Pharmacy,  Jamia Hamdard (Hamdard University),  New Delhi,  India.    Indian Journal of Heterocyclic Chemistry  (2004),  14(2),  163-164.  Publisher: Prof. R. S. Varma,  CODEN: IJCHEI  ISSN: 0971-1627.  Journal  written in English.    CAN 142:447068    AN 2005:82984    CAPLUS   (Copyright (C) 2006 ACS on SciFinder (R))   

Abstract

Starting from 3-(4-methylbenzoyl)propionic acid and using appropriate reagents some 2-arylidene-4-(4-methylphenyl)but-3-en-4-olides and corresponding pyrrolone derivs. were synthesized.

Bibliographic Information

Synthesis and anticonvulsant activity of 6-(substituted aryl)-2,3,4,5-tetrahydro-3-pyridazinones.      Siddiqui, Anees A.; Shahroz, Mir Mohammad; Amir, Mohammad.    Department of Pharmaceutical Chemistry, Faculty of Pharmacy,  Hamdard University,  New Delhi,  India.    Oriental Journal of Chemistry  (2004),  20(2),  303-306.  Publisher: Oriental Scientific Publishing Co.,  CODEN: OJCHEG  ISSN: 0970-020X.  Journal  written in English.    CAN 142:113996    AN 2004:988578    CAPLUS   (Copyright (C) 2006 ACS on SciFinder (R))   

Abstract

6-(Substituted aryl)-2,3,4,5-tetrahydro-3-pyridazinones were obtained from hydrazinolysis of the appropriate -(substituted aroyl)propionic acid.  The title compds. showed promising anticonvulsant activity when evaluated by Electroconvulsometer.

Bibliographic Information

3-(4-bromobenzoyl)propanoic acid.      Seed, Alexander J.; Sonpatki, Vaishali; Herbert, Mark R.    USA.    Organic Syntheses  (2003),  Volume Date 2002,  79  204-208.  Publisher: John Wiley & Sons, Inc.,  CODEN: ORSYAT  ISSN: 0078-6209.  Journal  written in English.    CAN 141:23258    AN 2004:342265    CAPLUS   (Copyright (C) 2006 ACS on SciFinder (R))   

Abstract

This method requires low reaction temps. and extended reaction times.  It provides consistently high yields and regioselective product formation and represents the first general method for the acylation of aryl compds. using succinic anhydride (dihydro-2,5-furandione).  The aluminum chloride-mediated Friedel-Crafts acylation of bromobenzene with dihydro-2,5-furandione gave 4-bromo--oxobenzenebutanoic acid.  A similar reaction of 2-bromothiophene with dihydro-2.5-furandione gave 5-bromo--oxo-2-thiophenebutanoic acid.

Bibliographic Information

Synthesis and antiinflammatory activity of 6-(substituted-aryl)-2,3,4,5-tetrahydro-3-thiopyridazinones.      Siddiqui, Anees A.; Kushnoor, Ashok; Wani, Sachin M.    Department of Pharmaceutical Chemistry, Faculty of Pharmacy,  Hamdard University,  New Delhi,  India.    Indian Journal of Heterocyclic Chemistry  (2004),  13(3),  257-260.  Publisher: Prof. R. S. Varma,  CODEN: IJCHEI  ISSN: 0971-1627.  Journal  written in English.    CAN 141:314269    AN 2004:298681    CAPLUS   (Copyright (C) 2006 ACS on SciFinder (R))   

Abstract

Title 6-(substituted-aryl)-2,3,4,5-tetrahydro-3-thiopyridazinones were synthesized via Friedel-Crafts acylation of appropriate hydrocarbons with succinic anhydride in presence of anhyd. aluminum chloride followed by cyclization of -(substituted-aroyl)-propionic acid with hydrazine hydrate and sulfuration with phosphorus penta-sulfide.  All thiopyridazinones exhibited dose dependent varying degrees of antiinflammatory activity at a dose level of 15 mg/kg when evaluated by rat paw edema method.  The substituents in the Ph group at 6-position of the thiopyridazinone ring have been found to exert variable effect on the antiinflammatory activity.  Thus, benzoylpropionic acid (I) was prepd. in 73% by reaction of benzene with succinic anhydride.  Cyclization of I with hydrazine hydrate gave 6-phenyl-2,3,4,5-tetrahydro-3-pyridazinone (II) in 80% yield.  Sulfuration of II with phosphorus penta-sulfide gave title compd. 6-phenyl-2,3,4,5-tetrahydro-3-thiopyridazinone in 65% yield.

Bibliographic Information

An alternative route to syntheses of aryl keto acids in a chloroaluminate ionic liquid.      Mohile, Swapnil S.; Potdar, Mahesh K.; Salunkhe, Manikrao M.    Dep. Chem.,  The Inst. Sci.,  Mumbai,  India.    Journal of Chemical Research, Synopses  (2003),   (10),  650-651.  Publisher: Science Reviews,  CODEN: JRPSDC  ISSN: 0308-2342.  Journal  written in English.    CAN 140:339017    AN 2004:172175    CAPLUS   (Copyright (C) 2006 ACS on SciFinder (R))   

Abstract

The Lewis acidic 1-butyl-3-methylimidazolium chloroaluminate ionic liq. [bmim]Cl.AlCl3, N=0.67, is employed as a catalyst as well as the solvent for the quick and efficient syntheses of aryl keto acids by Friedel-Crafts acylation and aroylation of arom. hydrocarbons using cyclic acid anhydrides.

Bibliographic Information

A simple procedure for the isolation of  -oxobenzenebutanoic acid derivatives: Application to the synthesis of fenbufen.      Srinivas, Ch.; Raju, C. M. Haricharan; Acharyulu, Palle V. R.    Technology Development Centre,  Custom Chemical Services Dr. Reddy's Laboratories,  Hyderabad,  India.    Organic Process Research & Development  (2004),  8(2),  291-292.  Publisher: American Chemical Society,  CODEN: OPRDFK  ISSN: 1083-6160.  Journal  written in English.    CAN 140:303369    AN 2004:129363    CAPLUS   (Copyright (C) 2006 ACS on SciFinder (R))   

Abstract

A simple, convenient, and industrially viable process for the isolation of 4-oxobutanoic acid derivs., resulting from Friedel-Crafts acylation of arom. hydrocarbons with succinic anhydride, is reported.  The isolation procedure involved simple quenching of the reaction mixt. followed by filtration to give the product in good yield and with excellent purity.  The generality of the procedure has been demonstrated with representative examples of arom. hydrocarbon precursors and has also been applied to the isolation of fenbufen (I).  The quantity of aluminum chloride used in the reaction has also been optimized to reduce the load on effluent.  



Bibliographic Information

Calorimetric Approach and Simulation for Scale-Up of a Friedel-Crafts Reaction.      Gigante, Lucia; Lunghi, Angelo; Martinelli, Simone; Cardillo, Paolo; Picello, Luca; Bortolaso, Roberto; Galvagni, Marco; Rota, Renato.    Stazione Sperimentale per i Combustibili,  San Donato Milanese,  Italy.    Organic Process Research & Development  (2003),  7(6),  1079-1082.  Publisher: American Chemical Society,  CODEN: OPRDFK  ISSN: 1083-6160.  Journal  written in English.    CAN 140:61304    AN 2003:876856    CAPLUS   (Copyright (C) 2006 ACS on SciFinder (R))   

Abstract

Exptl. calorimetric techniques and simulation techniques join together to optimize the scale-up of a Friedel-Crafts acylation.  The adopted methodol. involved the execution of isothermal tests at different temps., using the reaction calorimeter RC1, to obtain the heat flow vs. time data.  These data were used to perform a kinetic study of the reaction by using the simulation software BatchCAD.  The reliability of the adopted kinetic model was confirmed by comparing the exptl. data obtained by operating the desired reaction in adiabatic mode (in a Phi-Tec II calorimeter) with the predictions of the kinetic model in the same conditions.  Using this kinetic equation it was possible to simulate the process under pilot-plant conditions.  The good agreement between the model predictions and the exptl. data confirmed the accuracy of the kinetic equations.  Finally several large-scale prodn.-plant simulations were carried out varying both dosing time and reaction temp. to maximize the space/time yield and minimize the thermal risks.  This led to a high quality and safe process, saving a large part of the time (and money) usually spent in traditional scale-up procedures.

Bibliographic Information

An efficient and novel method for the synthesis of  -aroylpropionic acids under solvent-free conditions.      Mogilaiah, K.; Vasudeva Reddy, N.; Randheer Reddy, G.    Department of Chemistry,  Kakatiya University,  Warangal,  India.    Synthetic Communications  (2003),  33(18),  3109-3113.  Publisher: Marcel Dekker, Inc.,  CODEN: SYNCAV  ISSN: 0039-7911.  Journal  written in English.    CAN 140:93739    AN 2003:626348    CAPLUS   (Copyright (C) 2006 ACS on SciFinder (R))   

Abstract

A simple and rapid reaction of succinic anhydride with arom. hydrocarbons is described.  The reaction is conducted under Friedel-Crafts conditions in the absence of solvent at room temp. using aluminum chloride as catalyst.

[ Last edited by peak21st on 2006-6-22 at 12:11 ]
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咬定青山不放松，立根原在破岩中。千磨万击还坚劲，任尔东西南北风。
6楼2006-06-21 16:55:59
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