[交流] Informative diagnostics for personalized medicine

In addition to in vitro biomolecular
diagnostics, advanced imaging
technologies such as positron emission
tomography (PET) and functional
magnetic resonance imaging (fMRI) are
having an increasingly important role
in managing the treatment of disease,
and chemical biologists can make
substantial advances in the development
of informative diagnostic imaging
probes19. Disease-relevant small-molecule
metabolic probes, active site binders,
engineered proteins and new imaging
tags, such as magnetic and optically
active nanoparticles, will continue to help
physicians monitor the spread of disease.
The development of informative
diagnostic methodologies is crucial if the
biomedical research community is to realize
the full potential of molecularly targeted
therapeutics. Although early successes from
the modern drug discovery process have
offered hope for the personalized treatment
of disease, a grand challenge now lies in the
development of individualized diagnostic
tools—a challenge that must be met to
translate this promise into the improved
treatment of human disease. Chemical
biologists are well positioned to lead this
charge by expanding their efforts to include
the development of informative clinical
diagnostic methodologies, which should
include collaborations with scientists with
expertise in technologies that may just be
appearing on the horizon.

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