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于田9858

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[交流] Informative diagnostics for personalized medicine

In addition to in vitro biomolecular
diagnostics, advanced imaging
technologies such as positron emission
tomography (PET) and functional
magnetic resonance imaging (fMRI) are
having an increasingly important role
in managing the treatment of disease,
and chemical biologists can make
substantial advances in the development
of informative diagnostic imaging
probes19. Disease-relevant small-molecule
metabolic probes, active site binders,
engineered proteins and new imaging
tags, such as magnetic and optically
active nanoparticles, will continue to help
physicians monitor the spread of disease.
The development of informative
diagnostic methodologies is crucial if the
biomedical research community is to realize
the full potential of molecularly targeted
therapeutics. Although early successes from
the modern drug discovery process have
offered hope for the personalized treatment
of disease, a grand challenge now lies in the
development of individualized diagnostic
tools—a challenge that must be met to
translate this promise into the improved
treatment of human disease. Chemical
biologists are well positioned to lead this
charge by expanding their efforts to include
the development of informative clinical
diagnostic methodologies, which should
include collaborations with scientists with
expertise in technologies that may just be
appearing on the horizon.

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1楼 2010-12-05 20:37:14

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张军帅

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于田9858(金币+10, 翻译EPI+1): 2010-12-08 20:01:31

除了体内生物分子上的诊断，先进的成像技术如正电子断层扫描仪(PET)以及功能性核磁共振造影(fMRI)在治疗疾病上日益重要，化学生物学家在影像诊断学的探索上也取得了大量的进步。疾病相关的小分子代谢探针，活性部位粘合剂，工程蛋白以及新的成像标记物比如具有磁性和光学活性的纳米粒子将继续帮助内科医生监控疾病的蔓延，如果生物医学研究社群要实现分子靶标治疗上的全部潜能，诊断方法学的发展是最关键的，尽管现代药物发现过程的早期的成功已经为疾病的个性化治疗提供希望，巨大的挑战在于发展发展个体化诊断工具，这个挑战就是必须实现把这项期望转变成治疗人类疾病的改进方法，化学生物学家恰好处于通过他们的努力来知道这项使命以推动临床诊断方法学的发展的位置上。这就包括与技术上有专门知识科学家的合作，该技术可能已经初露端倪。

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