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Informative diagnostics for personalized medicine
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For newly discovered proteomic biomarkers, the development of stable and high-affinity capture agents represents a substantial hurdle¡ªone that chemical biologists are uniquely suited to attack. Monoclonal antibodies are the most commonly used capture agent for immunoassays, and although advances in hybridoma technology have led to the commercial availability of many thousands of antibodies, the cost and production time required to generate high-quality monoclonal antibodies against emerging biomarkers is often rate limiting. As substitutes for antibodies that feature more facile generation and improved stability, several alternative capture agents have been explored16, including aptamers17 and multivalent peptide scaffolds18, among many other exciting prospects. Chemical biologists have pioneered new strategies to develop capture agents and will continue to do so, given their aptitude in techniques such as ligand selection (for example, systematic evolution of ligands by exponential enrichment, or SELEX), library syntheses and bead-based screening approaches. |
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