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[交流] Informative diagnostics for personalized medicine

For newly discovered proteomic
biomarkers, the development of stable and
high-affinity capture agents represents
a substantial hurdle—one that chemical
biologists are uniquely suited to attack.
Monoclonal antibodies are the most
commonly used capture agent for
immunoassays, and although advances
in hybridoma technology have led to the
commercial availability of many thousands
of antibodies, the cost and production
time required to generate high-quality
monoclonal antibodies against emerging
biomarkers is often rate limiting. As
substitutes for antibodies that feature more
facile generation and improved stability,
several alternative capture agents have
been explored16, including aptamers17 and
multivalent peptide scaffolds18, among many
other exciting prospects. Chemical biologists
have pioneered new strategies to develop
capture agents and will continue to do so,
given their aptitude in techniques such as
ligand selection (for example, systematic
evolution of ligands by exponential
enrichment, or SELEX), library syntheses
and bead-based screening approaches.

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