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ufwtny(金币+1):谢谢参与
ufwtny(金币+5): 2010-12-09 08:53:46
qinhy(金币+1):多谢指教，欢迎常来药学版！ 2010-12-09 20:14:11
接肽的缩合反应中加入有机碱后才能发挥作用，类似你这种反应，将RCOOH和RNH2在瓶中，使用THF,CH2Cl2,DMF都可以，CH2Cl2比较常用，出现溶解以及产率问题时才考虑DMF（后处理需要减压蒸掉）， Aicd and amine in CH2Cl2 under ice bath
EDC was added in followed with TEA, stirring at o to room temperture overnight, TLC ,washed with NH4Cl(aq) NaCl (aq),dry by Na2SO4,concentrated
purifcation with chromatogram |
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