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草Q

木虫 (正式写手)


[交流] 【求助/交流】请问什么是Ⅰ型和Ⅱ型跨膜蛋白?有什么区别呢?O(∩_∩)O谢谢!

请问什么是Ⅰ型和Ⅱ型跨膜蛋白?有什么区别呢?O(∩_∩)O谢谢!菜鸟发问,希望有高手指点下,呵呵
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rainwander(金币+3):专业~~~鼓励积极参与~~~ 2011-01-07 21:15:12
What is a type I vs type II vs type II transmembrane protein?

Type I membrane proteins are single-pass transmembrane proteins which have their N-terminus exposed to the extracellular or luminal space, while type II membrane proteins have their C-terminus exposed to the extracellular or luminal space. Type III membrane proteins are multi-pass structures which are subdivided into IIIa and IIIb. The type IIIa have cleavable signal sequences while the type IIIb do not have a cleavable signal peptide and their N-terminus is extracellular.

http://answers.yahoo.com/question/index?qid=20060802152903AACcsC7

Asker's Rating:  Asker's Comment: You were ALMOST right, but got me on the right track... I finally found a source for the specifics.
Type I: N terminal signal sequence, cleaved, C terminal cytoplasmic tail.
Type II: No signal sequence, C terminal lumenal, N terminal cytoplasmic
Type III: Same as II, but N is lumenal, C it cyto

[ Last edited by brightfuture01 on 2011-1-7 at 14:29 ]
4楼2011-01-07 14:27:44
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laoshu16

银虫 (小有名气)



草Q(金币+1):谢谢参与
α螺旋束和β桶?
2楼2011-01-07 14:10:00
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laoshu16

银虫 (小有名气)



小木虫(金币+0.5):给个红包,谢谢回帖交流
莫非是指的拓扑学结构,N端C端朝向?
3楼2011-01-07 14:15:21
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沧海激流

新虫 (初入文坛)



小木虫: 金币+0.5, 给个红包,谢谢回帖
根据singer分类法(singer classification )( On the transfer of integral proteins into membranes) Proc. Nati. Acad. Sci. USA
Vol. 84, pp. 1960-1964, April 1987
可以将膜内在蛋白质分为以下6个类型:
1、I型:一次跨膜,N外C内
2、II型:一次跨膜,N端在细胞内部内C外
3、III型:多次跨膜,以4次和7次跨膜多见
4、IV型:由多个亚单位组成的跨膜通道
5、V型:多肽链以糖基磷脂酰肌醇(GPI)连接于细胞膜的脂质双层中。
6、VI型:一条多肽链的一端以GPI形式连接于胞桨膜,另一端是一次或多次跨膜
5楼2013-12-11 14:10:04
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