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panyulian0

金虫 (小有名气)

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虫号: 1053857
注册: 2010-07-08
专业: 有机合成

[交流] 应急应急应急！！！！！！！！！求翻译！

A sol–gel imprinted with N-[N-[(1S)-1-carboxy-3-
phenylpropyl]-l-lysyl]-l-proline, lisinopril dihydrate, was
successfully synthesised which illustrated enhanced selectivity
by the MIP over a NIP. Specificity of the MIP for the
template over two of its listed related substances was also
achieved. It was noted that the quantity of lisinopril reloaded
onto the polymeric material was important in observing selectivity
for the template. Optimisation of loading illustrated
the binding capacity of the polymer. When the polymer was
saturated with template, selectivity was lost. A key factor in
optimising selectivity was found to be the solvent in which
the template was dissolved for rebinding. The loading solvent,
which gave best selectivity for lisinopril, was the porogen
used in the synthesis of the original polymeric material. It
was noted that a certain degree of cross-linker must be present
in order for the polymer to form and for optimum template
selectivity but at higher concentrations selectivity was lost.
For the functional monomers it was noted that the – interacting
monomer (PTMOS) was required in small quantities
to produce a selective medium. The smallest change in the
concentration of hydrogen bonding species (APTES) greatly
affected selectivity of the polymer. Above and below the optimum
ratio of 1.5, selectivity was lost and almost complete
retention of the template by both NIP and MIP was observed.
Reproducible responses were noted for both NIP and MIP
materials for the template over an 8-month-time-period. Further
optimisation of this polymeric system is envisaged in order
to reduce the observed non-specific binding of template
by the NIP.

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思维一直在变。

1楼2010-10-31 21:13:35

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

大象XXY

银虫 (小有名气)

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注册: 2010-01-25
专业: 生物化学

panyulian0(金币+10, 翻译EPI+1):很好，谢谢。 2010-11-13 12:40:15

由N-｛N-[(S)-1-羧基-3-苯丙基]-L-赖氨酰｝-L-脯氨酸二水合物印迹的溶胶凝胶，已成功合成，表现出MIP强于NIP的高选择性。对于其所列的相关底物，MIP对其中超过两类表现出特异性。值得注意的是，重装到聚合物材料中的赖诺普利数量，在观测其对模板的选择性方面很重要。装载的优化主要表现在聚合物的结合能力上。当聚合物
与模板饱和时，其选择性会丢失。优化选择性的一个关键因素被发现为溶解模板的溶剂，模板在其中需被解散然后重新绑定。而对赖诺普利选择性最好的装载溶剂，是原始的用于高分子材料合成的致孔剂。值得注意的是，必须存在一定程度的交联，以助于聚合物的形成以及模板选择性的最优化，因模板浓度较高时，选择性会丢失。对于功能性单体而言，需注意要求含有小批量相互作用的单体(PTMOS)以用于生产选择性培养基。在氢键浓度（APTES）上极小的变化，都可极大地影响聚合物的选择性。在最佳比例1.5上下，聚合物的选择性即已丢失，在NIP和MIP中均发现基本可完整地保留模板。为期八个月的实验，观察了针对NIP和MIP对材料模板进行的再生性反应。对这一聚合物系统进一步优化的设想，即降低观察到的NIP对模板的非特异性结合。