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The antimicrobial activity of an extract from the pharmacologically useful herb Ruta chalepensis has been traced by bioassayguided fractionation to an unusual component, quinoline-4- carbaldehyde 1. While the authors make no mention of the fact, this compound has apparently never before been found in plants, although it has previously been isolated from the myxobacterium Archangium gephyra.The compound strongly inhibited the growth of Clostridium perfringens, a noxious component of human gastrointestinal microflora, but its effect on Escherichia coli was weaker. It had little or no effect on the beneficial gastrointestinal bacteria Bifidobacterium bifidum, B. longum and Lactobacillus acidophilus, which perhaps explains the phytoprotective effects of the herbal remedy. |
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wangrui-jida(½ð±Ò+3, ·ÒëEPI+1): 2010-09-26 16:35:57
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