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原文： Cellular accumulation alone is insufficient to enable activity; any potential agent must also be able to reach its target within the cell. As many metal complexes are targeted to DNA, they must furthermore gain nuclear access, which is tightly regulated by the nuclear pore complex (NPC).58 [58] Nigg, E. A. Nature 1997, 386, 779-787. 出现在文章中的句子：For anticancer agents, cellular accumulation alone was insufficient to enable antiproliferative activity, and the potential therapeutic agent must also be able to reach its target within the cell. For DNA-targeted agent, they must furthermore gain nuclear access, which was tightly regulated by the nuclear pore complexes (NPCs).51 [51] Terry, L.; Shows, E.; Wente, S. Science 2007, 318, 1412-1416. |
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