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Synthesis of enantiomerically pure 4-aryl-3,4-dihydro- pyrimidin-2(1H)-ones via enzymatic resolution: preparation of the antihypertensive agent (R)-SQ 32926 A practical and short synthesis of the enantiomerically pure dihydropyrimidone antihypertensive agent (R)-SQ 32926 has been developed. The key step in the synthesis is the enzymatic resolution of an N3- acetoxymethyl-activated dihydropyrimidone precursor by Thermomyces lanuginosus lipase. The absolute con®guration of (R)-SQ 32926 was con®rmed by circular dichroism spectroscopy. # 2000 Elsevier Science Ltd. All rights reserved. |
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