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Synthesis of enantiomerically pure 4-aryl-3,4-dihydro- pyrimidin-2(1H)-ones via enzymatic resolution: preparation of the antihypertensive agent (R)-SQ 32926 A practical and short synthesis of the enantiomerically pure dihydropyrimidone antihypertensive agent (R)-SQ 32926 has been developed. The key step in the synthesis is the enzymatic resolution of an N3- acetoxymethyl-activated dihydropyrimidone precursor by Thermomyces lanuginosus lipase. The absolute con®guration of (R)-SQ 32926 was con®rmed by circular dichroism spectroscopy. # 2000 Elsevier Science Ltd. All rights reserved. |
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¡ï
wypward(½ð±Ò+1):лл²ÎÓë 2010-09-13 11:01:19
huchengc(½ð±Ò+30, ·ÒëEPI+1): 2010-09-13 15:04:43
wypward(½ð±Ò+1):лл²ÎÓë 2010-09-13 11:01:19
huchengc(½ð±Ò+30, ·ÒëEPI+1): 2010-09-13 15:04:43
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ͨ¹ýø²ð·Ö·¨ºÏ³É¹âѧ´¿4-·¼»ù-3,4-¶þÇâà×à¤-2-ͪµÄ£º¿¹¸ßѪѹҩ(R)-SQ 32926µÄÖÆ±¸ ±¾ÎÄÌá³öÁËÒ»ÖÖ¿ìËٺϳÉXXµÄ¿ÉÐз½·¨¡£¹Ø¼ü²½ÖèÊÇÓÃÊÈÈÈÕæ¾úÖ¬·¾Ã¸²ð·ÖN3-´×Ëá»ù¼×»ù»î»¯µÄ¶þÇâà×à¤Ç°Ìå¡£Ô²¶þÉ«Æ×±íÃ÷ (R)-SQ 32926 ±»ÍêÈ«·ÖÀë¡£ |
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