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Synthesis of enantiomerically pure 4-aryl-3,4-dihydro-
pyrimidin-2(1H)-ones via enzymatic resolution:
preparation of the antihypertensive agent (R)-SQ 32926

A practical and short synthesis of the enantiomerically pure dihydropyrimidone antihypertensive agent
(R)-SQ 32926 has been developed. The key step in the synthesis is the enzymatic resolution of an N3-
acetoxymethyl-activated dihydropyrimidone precursor by Thermomyces lanuginosus lipase. The absolute
con®guration of (R)-SQ 32926 was con®rmed by circular dichroism spectroscopy. # 2000 Elsevier Science
Ltd. All rights reserved.

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cam967

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wypward(½ð±Ò+1):лл²ÎÓë 2010-09-13 11:01:19
huchengc(½ð±Ò+30, ·­ÒëEPI+1): 2010-09-13 15:04:43
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