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| 糖尿病时，肾素-血管紧张素系统(renin-angiotensin system，RAS)被激活，升高的血管紧张素Ⅱ(AngⅡ)通过细胞表面的AT1受体，刺激心肌成纤维细胞增生及胶原代谢改变，引起心脏结构重塑，导致心肌间质及血管周围纤维化，胶原含量增多和排列紊乱，造成心室肌僵硬而影响舒张功能，出现糖尿病心肌病(diabetic cardiomyopathy，DCM)的临床症状。本文从RAS的主要成分Ang Ⅱ、Ang-(1-7)、Ac-SDKP和管紧张素受体(ATR)入手，阐述了RAS在糖尿病心肌病发生发展中所起的重要作用。 |
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momo_458(金币+12, 翻译EPI+1): 2010-08-28 09:57:00
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Diabetes, the renin - angiotensin system (renin-angiotensin system, RAS) is activated, elevated angiotensin Ⅱ (Ang Ⅱ) AT1 receptor by cell surface and stimulate cardiac fibroblast proliferation and collagen metabolism changes cardiac remodeling, resulting in myocardial interstitial and perivascular fibrosis, and disordered collagen content increased, resulting in ventricular stiffness affect diastolic function, heart disease to diabetes (diabetic cardiomyopathy, DCM) of the clinical symptoms. In this paper, the main component of RAS Ang Ⅱ, Ang-(1-7), Ac-SDKP and Angiotensin Receptor (ATR) and expounds the RAS in the development of diabetic cardiomyopathy played an important role. This article comes from: wooden insect Forum https://muchong.com/bbs/viewthread.php?tid=2329874&fpage=2 |
2楼2010-08-27 14:16:33