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[½»Á÷] ¡¾Ô­´´¡¿¡¶Organic Letter¡·Í¶¸å¹ý³Ì[ÒÑËÑË÷£¬ÎÞÖØ¸´]

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Ͷ¸åÐÅ(ÕâÊÇÎҵĽö¹©²Î¿¼)

Dear Editors and Referees:

The ************* is a useful method for the production of *************** which are important pharmaceutical intermediates. It is known that the ***************** has been achieved with excellent enantioselectivity. In sharp contrast, the use of ********************* has been proven much more challenging. As a result, few **** have been reported to ******************. ********* reported a *************************with moderate yields and enantioselectivities. However, the ****************** is substantially less effective for ***** substrates. In the same year, ***** and his co-workers described the ************ in the presence of *************** with high enantioselectivities and yields. Subsequently, ************ and our group have reported*************. Although the advances have been achieved, ************, *************, or other ********** must be employed. Here, we reported a efficient system for *****************.
a)  This is the first example of highly efficient********* which could **********************.
b)        Our ******** employs no additional ************ or the **************. This has greatly simplified the experimental procedure for this reaction.
We would like to submit the manuscript to Org. Lett (communication) for publication. It would be highly appreciated if you give a favorable consideration on it.

Sincerely yours,

µÚÈý:

ÎÄÕÂͶ³ö
ϵͳ»Ø¸´:
>Dear Dr.:
Your manuscript
Manuscript Title: ****************************************was received in the editorial offices of Organic Letters on 10-MAR-05.
Thank you for submitting your work to Organic Letters.
Submission of a manuscript to Organic Letters implies that the work reported
therein has not received prior publication and is not under consideration for
publication elsewhere in any medium, including electronic journals and computer
databases of a public nature. This manuscript is being considered with the
understanding it is submitted on an exclusive basis. If otherwise, please advise.
When your manuscript has been assigned an editor, you will receive a second email
containing the fax number or mailing address to which you should send your
copyright form.
If you submitted this manuscript as the Corresponding Author, you may find it
convenient to share your security key.  The security key allows one other person
to submit a revision to the manuscript and/or track the manuscript's status on
their own Paragon home page.
If the manuscript was submitted on your behalf, its status does not currently
display on your Paragon home page.  Use the security key to add this manuscript to
your Paragon home page.
Please remember that only the Corresponding Author and one other person may track
a manuscript's status at one time.
Sincerely,
Editor-in-Chief, Organic Letter

Ò»°ãµÚ¶þÌì¾Í»á¸øÄã·ÖÖ÷±à,Äã¿ÉÒÔ½øÄãµÄͶ¸åÖ÷Ò³ÉÏ¿´µ½·ÖÅ䏸ÄãµÄÖ÷±à.
Õâʱ,ÄãµÄ½øÃÀ¹ú»¯Ñ§»áÏÂÔØ°æÈ¨,Ç©Ãûºó(Ö÷ÒªÊǵÚÒ»×÷ÕߺÍͨѶ×÷Õß)·¢Íù·ÖÅ䏸ÄãµÄÖ÷±à.ÕâÒ»µãºÜÖØÒª,ÒòΪÄã²»·¢°æÈ¨,Ö÷±à¾Í²»»á¸øÄãËÍÉó¸åÈË!!!!!!

µÚËÄ
Èç¹ûÄãÔÚÉó¸åÆÚ¼äͨ¹ýϵͳ¸ú×ÙÄãµÄÎÄÕÂ
»áÓÐÒÔÏ»ظ´:
This email is to inform you that the person who is tracking your manuscript "************************************************",  ************has changed.
Previously it was being tracked by *****.  Effective immediately it is being
tracked by *****.

Please remember that only two people, the Corresponding Author and one other
person, may track a manuscript at one time.  If you choose to share your
manuscript number and security key with additional parties for the purpose of
tracking, the newer party will overwrite any previous person who was tracking the
manuscript.  New parties will not overwrite your ability to track your
manuscript.

ûÓйØÏµ,Òâ˼ÊÇ˵ֻÔÊÐíÄãºÍͨѶ×÷Õ߸ú×ÙÎÄÕÂ

µÚÎå:
ÎÄÕÂÓÐÏûÏ¢(Ò»°ãÒ»¸öÔÂ)
Dear Prof.***:

Your paper has been reviewed and I would be happy to accept it after
the attached reviewer comments and the items indicated on the revision
request form have been addressed. Please include a detailed letter with
your revision, itemizing the changes you have made in the manuscript.

TO REVISE YOUR MANUSCRIPT ON THE WEB:
-------------------------------------
NOTE: Please submit your revision using your Paragon home page.

1.        Log on to your Paragon home page at http://paragon.acs.org.

2.        Scroll to the section titled: 'Revisions required by
        Editorial Office.'
        - Click on the manuscript number* to submit a revision.

3.      Follow the directions in Paragon to complete the submission
        of your revision.

[* In the event this manuscript is not listed on your home page:
        - Click on the 'Revise Manuscript' button to add the
          manuscript to your home page and revise the manuscript
        - Enter the manuscript number and security key as follows:
             Manuscript Number: *******
             NOTE: All manuscript numbers begin with the letters
              'ol' followed by 6 numbers. The last
               character can be either a letter, a number,
               or a '+' sign.
             Security Key: ******
        - Click on "Add Paper"
        - The manuscript should now appear in the
          'Revisions required by Editorial Office' section
  Continue with steps 2 and 3 above. ]


Submitting Supporting Information (SI):

At Step 3 of the submission process, 'Upload Documents', you will see a
list of all of the SI files you originally submitted. You can add or
delete files. If you have changed a file, you must remove it and upload
the new version. You must submit a manuscript in order to submit
revised SI. (If there are no changes to your manuscript, simply
resubmit the original manuscript.)

As you know, Organic Letters aims for quick turnaround time from
submission to publication; therefore, we ask that you complete your
revision within 7 days. Please let us know if you need more time. We
will publish a revision date if revision takes over 30 days, unless
there are extenuating circumstances.

Sincerely,

Éó¸åÒâ¼û:
1#
Recommendations regarding the manuscript MS NO: ***********

2.________Publish after minor revisions noted below


Overall importance of this paper ¨C 8/10

The manuscript **************by ****** and coworkers suggests a novel methodology for ******* to *********8 with low ligand loading. This work contributes to an intensively investigated field of enantioselective ************. In particular, addition of ************ still lacks noteworthy achievements in terms of enantiomeric purity of tertiary propargylic alcohols, obtained in this transformnation. The ligands utilized in this manuscript are straightforwardly synthesized from commercial amino acids and used in remarkably low catalytic quantities, as compared to the methods reported so far. Enantiomeric purities of final products as well as isolated yields are in the range of reasonable to high. The described methodology doesn¡¯t require use of additional Lewis acid, thus simplifying the overall process. The discussed manuscript is recommended for publication with minor revisions presented below.

Comments referring to the manuscript:
¡¤        Several sentences are bad formulated and should be phrased differently
¡¤        Several grammar mistakes were found in the present text
¡¤        Several misspellings were found in the references part and should be ommited (i.e., names of journals as well as names of authors)
¡¤        References 9(k) was not found on the indicated page (JACS, 2005, 127, 3137). This paper appears on the page 1313 of the indicated issue.
¡¤        Scheme 2: It is recommended to add ¡°R=***¡± and ¡°R=*****¡± to the compounds ** and *** respectively, to make the Scheme more clear
¡¤        Ligand *** appears in Figure 1, although no species under this number are mentioned in the text
¡¤        Table 1 ¨C it¡¯s recommended to add a footnote with the amount of substrate used in this transformation, otherwise the stoichiometry of  diethylzinc is unclear

Comments referring to the experimental part:
¡¤        From Table 1 one can conclude that the reaction is conducted at -18C for 48h. It appears, however, in the synthetic protocol, that the reaction mixture was actually stirred at r.t. for ********.
¡¤        For more convenient reading and correlating between the data in the text and in the experimental part, it¡¯s recommended to assign numbers to the obtained products
¡¤        The chiral HPLC column used in the present work for ee% determination is mentioned as Chiracel OD-H in the text, but Chiracel OD in the experimental part

2#
Manuscript Number: ********
Manuscript Title: ************
Alcohols Corresponding Author:  ********


Rate the overall importance of this paper to the field of Organic Chemistry

10 - High Importance / 1 - Low Importance:  8


Recommendation: Publish after minor revisions noted below.

Additional Comments: The manuscript "*****************************" by ************** and coworker is a quite interesting and useful piece of work. Wang and coworkers were able to find a suitable, easily prepared and inexpensive ligand that make possible the addition of acetylides to ketones in very low loading. These are un-precedent results that could open new perspective in the formation of quaternary stereocenters. In-fact, an immediate extension to the present communication is the behavior of the ligands in addition of simple *******, functionalized zinc reagents, or *********8 reagents to ********. Until now, only few successful studies has been published by ****, ******* and **********. ************8's ligand probably can be also used in these processes, and therefore, this paper is highly recommended for Org. Lett.
Minor points. In a note a comment about the reactivity of aliphatic ketone could be useful to readers.
In note, there are correction to introduce:
Reference 1 (b). Comeprehensive Asymmetric Catalysis.
Reference 2 (k). Hems, and publications year 2006.
Reference 3(g). ************.;
Reference 3 (k). *******.;
9 (e). Yorozu, K
Reference 9 (f). Authors are missing:  (f) Belokon', Y, R.; Caveda-Cepas, S.; Green, B.;  Ikonnikov, N. S.; Khrustalev, V. N.: Larichev, V. S.; Moscalenko, M. A.; North, M.; Orizu, C.; Tararov, V. I.; Tasinazzo, M.; Timofeeva G. I., Yashkina, L. V.3968 - 3973.
Reference 9 (h). Irvine, D. J.
Reference 9 (i). Kevin W. Kuntz.
Reference 9 (k).J. Am. Chem. Soc. (introduce a space between Am. and Chem..);  page 1313-1317.

In the experimental details (page S2), it is not clear if the reaction is carried out at -18 ¡ãC for 48 hours, or the mixture is warmed up to RT after the addition of the ketones.
The experimental results are adequately commented and the work appears well reproducible.
The Supporting Information HPLC analytical data are clearly prepared, and the quality of the reported spectra is acceptable.



ÎҵĻظ´ÐÅ:

Dear Editor and referees:
We are highly appreciating you for giving us an opportunity to revise the manuscript. We have modified the manuscript according to editor¡¯s and two reviewers¡¯ requirement.

<1> According to editor¡¯s requirement:
1.        We have adjusted the size of Table 1, 2 and 3. The graphics were also modified according your suggestions.
2.        Thank you very much for your modifications on our MS. We have changed these errors in MS.

<2> According to reviewer¡¯s requirement:
1.        Answer for your minor points, we have addressed it in the MS.
2.        Thank your detail suggestion. We have corrected the references in MS[References 1 (b), 2 (k), 3 (g), 3 (k), 9 (e), 9 (f), 9 (h), 9 (i) 9 (k)].
3.        The resulting mixture was stirred for *****h at ****¡ãC (In supporting information S2, line 4 from the bottom)


<3> According to reviewer¡¯s requirement:
1.        The errors you mentioned we have modified. These have been addressed in the answer for editor¡¯s requirement and the other reviewer¡¯s requirement.
2.        We have added ¡°R=**** and R=*******¡± to the compounds 7a and 7b respectively(Scheme 2).
3.        The number 3 of Ligand 3 in Figure 1 was inserted in the MS(page. 1, line 5 from the bottom).
4.        The resulting mixture was stirred for *****h at -******¡ãC (In supporting information S2, line 4 from the bottom)
5.        A footnote was added to Table 1 about the amount of acetophenone(Table 1, footnote a)
6.        The chiral HPLC column in our MS and Suppporting information are all use Chiracel OD-H (See the last sentence of General Experimental Details).
7.        We have inserted the structure in the correlating produces for convenient reading(see souporting information S3-S5).



All the modifications of the manuscript have been explained, and it would be highly appreciated if you are so kind to give a favorable consideration on it.
At last, we added three references in References 2 (2c, 2d, 2g).
Sincerely yours,
Õâʱºò
ÄãͶ¸åÖ÷Ò³
״̬Ҳ»áÓб仯.Ö÷±à»áÒªÇóÄãÐÞ¸Ä.

µÚÁù:
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ÎÒûÓи㶮Ö÷±àÒâ˼
Ö÷±àÓÖ»ØÐÅÒªÇó´ÓÐÂÐÞ¸Ä
Dear Prof.*********:

Thank you for the submission of your revised paper.  There is still one
minor issue that needs to be addressed.  As you can see in the
Manuscirpt Revision Request form, a version of your manuscirpt hi-
lighting the changes you have made is required.  Please provide
this "Track changes" version.


Sincerely,

¾­Ñé:
Ö÷±àËùÖ¸¶¨"track changes"
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