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结果 氟单独染毒组大鼠氟斑牙症状明显。与溶剂对照组相比，氟单独染毒组大鼠肝脏中GSH-Px、SOD活力降低，MDA含量升高，差异均有统计学意义(P<0.05)；高浓度硒单独染毒组SOD活力降低，差异均有统计学意义(P<0.05)。与氟单独染毒组相比，中、高浓度硒单独染毒组和高浓度硒+氟联合染毒组大鼠肝脏中GSH-Px活力上升，差异均有统计学意义(P<0.05或P<0.01)；低、中浓度硒单独染毒组SOD活力上升，差异均有统计学意义(P<0.05)；中浓度硒单独染毒组和高浓度硒+氟联合染毒组MDA含量下降，差异均有统计学意义(P<0.05)。各染毒组大鼠肝脏中T-AOC活力间比较，差异无统计学意义。与溶剂对照组相比，氟单独染毒组和低浓度硒+氟联合染毒组大鼠肝组织中NF-κB表达水平升高，差异均有统计学意义(P<0.05)。与氟单独染毒组相比，低浓度硒单独染毒组大鼠肝组织中NF-κB表达水平降低，差异有统计学意义(P<0.05)。病理学结果显示，氟+硒联合染毒组大鼠肝细胞变性坏死程度明显减轻，且肝细胞变性坏死程度随着硒染毒浓度的升高而呈下降趋势。
Results Fluoride single exposure group showed obvious symptoms of dental fluorosis. Compared with the control, the GSH-Px, SOD activity in rat liver from fluoride single exposure group decreased, and MDA content increased, the differences were statistically significant (P <0.05); the SOD activity of high concentrations of selenium single exposure group reduced, the differences were statistically significant (P <0.05). Compared with single exposure group, the GSH-Px activity of high concentrations of selenium single exposure group and the high concentration of selenium-fluoride combined exposure group in rat liver increased, the differences were statistically significant (P <0.05 or P <0.01); the SOD activity of low concentrations and middle concentrations of selenium in the single exposure group increased, the differences were statistically significant (P <0.05); the MDA content of middle concentration of selenium single exposure group and the high concentration of fluoride- selenium combined exposure group was decreased, the differences were statistically significant (P <0.05). The differences of T-AOC activity in Liver of rats among all exposure groups difference were not statistically significant. Compared with the control group, NF-κB expression level in rat liver from fluoride single exposure group and the low fluoride concentration combined with selenium exposure group, the differences were statistically significant (P <0.05). compared with Fluoride single exposure group, the NF-κB expression level in rat liver from low concentration of selenium single exposure group decreased significantly (P <0.05). Pathology results showed the rats from fluoride-selenium combined exposure ameliorate significantly the degeneration and necrosis of liver cells, and the extent of degeneration and necrosis of liver cells decreased with the rise of the concentration of selenium. |
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