| 查看: 883 | 回复: 5 | ||
| 【奖励】 本帖被评价1次，作者liuxingxp增加金币 0.5 个 | ||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | ||
[资源]
【资源】关于能够抵御所有抗生素的超级病菌的柳叶刀论文,新鲜送上
|
||
|
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study Summary Background Gram-negative Enterobacteriaceae with resistance to carbapenem conferred by New Delhi metallo-β- lactamase 1 (NDM-1) are potentially a major global health problem. We investigated the prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK. Methods Enterobacteriaceae isolates were studied from two major centres in India—Chennai (south India), Haryana (north India)—and those referred to the UK’s national reference laboratory. Antibiotic susceptibilities were assessed, and the presence of the carbapenem resistance gene blaNDM-1 was established by PCR. Isolates were typed by pulsed-fi eld gel electrophoresis of XbaI-restricted genomic DNA. Plasmids were analysed by S1 nuclease digestion and PCR typing. Case data for UK patients were reviewed for evidence of travel and recent admission to hospitals in India or Pakistan. Findings We identifi ed 44 isolates with NDM-1 in Chennai, 26 in Haryana, 37 in the UK, and 73 in other sites in India and Pakistan. NDM-1 was mostly found among Escherichia coli (36) and Klebsiella pneumoniae (111), which were highly resistant to all antibiotics except to tigecycline and colistin. K pneumoniae isolates from Haryana were clonal but NDM-1 producers from the UK and Chennai were clonally diverse. Most isolates carried the NDM-1 gene on plasmids: those from UK and Chennai were readily transferable whereas those from Haryana were not conjugative. Many of the UK NDM-1 positive patients had travelled to India or Pakistan within the past year, or had links with these countries. Interpretation The potential of NDM-1 to be a worldwide public health problem is great, and co-ordinated international surveillance is needed. Funding European Union, Wellcome Trust, and Wyeth. 全文下载地址 http://www.91box.net/?B60NOMJHOWETK6YA7ECW [ Last edited by liuxingxp on 2010-8-12 at 20:31 ] |
回复此楼» 猜你喜欢
实验答疑室丨先养细胞还是先上小鼠
已经有0人回复
-
一文理清cDNA与gDNA的区别
已经有0人回复
-
遗传学与生物信息学论文润色/翻译怎么收费?
已经有215人回复
-
跑了那么多次WB，你真的知道它在测什么吗
已经有0人回复
-
西综306 一志愿江苏临检总分324求调剂
已经有1人回复
-
实验答疑室丨修饰即命运--MDL解读PTMs
已经有0人回复
-
WB实验避坑指南！多条带＋高背景？十大原因逐一分析
已经有0人回复
-
实验答疑室丨细胞培养总失败？MDL带您避开90%的污染源！
已经有0人回复
-
一文讲清实验室各种常见的细胞模型
已经有0人回复
-
科研干货|一文搞懂甲基化（组蛋白+DNA+RNA）
已经有0人回复
-
手把手教学 | 小鼠如何高效灌胃给药？
已经有0人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 武汉理工大学学报英文版
已经有7人回复
- 审稿人询问试验重复次数，该如何回答？
已经有12人回复
- 第一次收到REview外文文章的邮件，本人没有经验，请给些意见和建议？
已经有7人回复
- 谁遇到过这种审稿回复，是婉拒吗？
已经有39人回复
- 论文数据处理
已经有6人回复
- 论文小修还用返给审稿人吗
已经有13人回复
- 论文已修回，但是发现一处错误怎么办？
已经有8人回复
- RSC的杂志，拒稿重投（reject and resubmssion）还需要回复审稿人意见吗？
已经有6人回复
- 先投会议，再投期刊，算多投吗？
已经有11人回复
- Nanotechnology 投稿 Not refereed 什么意思？
已经有6人回复
- 哪个更值得：书的其中一个chapter和一篇2分的SCI文章
已经有19人回复
- 大家有了解NPG Asia Materials 这个杂志的么？
已经有3人回复
- 请教Spring杂志中e-offprints和电子版的彩图是否收费
已经有6人回复
- 抗生素的环境行为
已经有8人回复
- 论文discussion翻译
已经有2人回复
- 【讨论】《柳叶刀》论文：“超级病菌”能抵御几乎所有抗生素（附相关论文地址）
已经有8人回复
4楼2010-08-14 16:06:52
2楼2010-08-12 21:37:13
3楼2010-08-12 22:31:21
|
我个人对此问题的认识是以下三点： 抗生素滥用是外部原因，而非临床环境中存在着耐药基因才是内因。此外，目前超级细菌无药可治，也凸显了抗生素研发的不足。 关于此三点详细论述，请参考 前几天发的两篇科技评述。 南方周末 http://www.infzm.com/content/49096 科技日报 http://www.stdaily.com/kjrb/content/2010-08/19/content_220405.htm 希望战友，批评指导 说的有道理，请投票。谢谢  |
5楼2010-08-25 14:50:25
10