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木虫 (职业作家)

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[交流] 求助校对英文

6-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime在不同的酸及溶剂条件下进行贝克曼反应时，总是得到少量的2,3,4,5-tetrahydro-7-methoxy-1H-2-benzazepin-1-one，而其另一个同分异构体为主产物。最近，我们发现贝克曼重排产物的组成分布随着反应的温度和时间有较大的变化。我们合成并培养了标题物质以便于研究反应条件对两种同分异构体产物的比例的影响。顺反式对甲苯磺酸酯的比例可以通过核磁共振H谱的积分面积来求得。本文报导标题物质的单晶结构。

2,3,4,5-tetrahydro-7-methoxy-1H-2-benzazepin-1-one was always minor product while its another major isomer was 1,3,4,5-tetrahydro-7-methoxy-2H-1-benzazepin-2-one when 6-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime carried out the Beckmann reaction with different acid ang solvent. Recently, we have found the product distribution of the Beckmann rearrangement greatly varied with reaction time and temperature. We synthesized and trained the title compound in order to study the effect of the reaction conditions on the ratio of the two isomers of product. The trans/cis ratio of tosylates was calculated on the basis of NMR integration. In this paper, we report the crystal structure of the title compound.

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