24小时热门版块排行榜    

查看: 3350  |  回复: 11
当前只显示满足指定条件的回帖,点击这里查看本话题的所有回帖

lsss

木虫 (正式写手)

121-水手

[交流] 【求助/交流】外显子和内含子?? 已有8人参与

用NCBI的SPLIGN分析牛ACACA基因,结果发现其有56个外显子,其CDS为341-7381。即图中显示,其编码启始位点在第三个外显子内,难道其第一、第二外显子都在UTR区?那还叫外显子吗?很困惑,请各位虫友指点,多谢!!!
回复此楼
昔日寒山问拾得曰:世间谤我、欺我、辱我、笑我、轻我、贱我、恶我、骗我、如何处治乎?拾得云:只是忍他、让他、由他、避他、耐他、敬他、不要理他、再待几年.
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

lsss

木虫 (正式写手)

121-水手

★ ★ ★ ★
看天(金币+4):求助者助人 大家互助分享 这是一种值得鼓励的精神 2010-08-02 17:42:27
感谢楼上两位兄弟的解释,我又在维基百科搜索了外显子的含义,这回算是弄明白了,下面是一部份解释,贴出来共享:
In many genes, each exon contains part of the open reading frame (ORF) that codes for a specific portion of the complete protein. However, the term exon is often misused to refer only to coding sequences for the final protein. This is incorrect, since many noncoding exons are known in human genes (Zhang 1998).

To the right is a diagram of a heterogeneous nuclear RNA (hnRNA), which is an unedited mRNA transcript, or pre-mRNAs. Exons can include both sequences that code for amino acids (red) and untranslated sequences (grey). Stretches of unused sequence called introns (blue) are removed, and the exons are joined together to form the final functional mRNA. The notation 5' and 3' refer to the direction of the DNA template in the chromosome and is used to distinguish between the two untranslated regions (grey).

Some of the exons will be wholly or part of the 5' untranslated region (5' UTR) or the 3' untranslated region (3' UTR) of each transcript. The untranslated regions are important for efficient translation of the transcript and for controlling the rate of translation and half life of the transcript. Furthermore, transcripts made from the same gene may not have the same exon structure since parts of the mRNA could be removed by the process of alternative splicing. Some mRNA transcripts have exons with no ORF's and thus are sometimes referred to as non-coding RNA.


昔日寒山问拾得曰:世间谤我、欺我、辱我、笑我、轻我、贱我、恶我、骗我、如何处治乎?拾得云:只是忍他、让他、由他、避他、耐他、敬他、不要理他、再待几年.
9楼2010-08-02 10:37:43
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
查看全部 12 个回答

fppzcz

铜虫 (初入文坛)

★ ★ ★
小木虫(金币+0.5):给个红包,谢谢回帖交流
1949stone(金币+2):学习交流 2010-07-30 15:30:48
不明白,但是个人感觉1.2应该属于前导肽类似的功能,
 UTR(Untranslated Regions)即非翻译区,是mRNA分子两端的非编码片段。
  5'-UTR从mRNA起点的甲基化鸟嘌呤核苷酸帽延伸至AUG起始密码子,3'-UTR从编码区末端的终止密码子延伸至多聚A尾巴(Poly-A)的末端。
2楼2010-07-30 15:10:05
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

lsss

木虫 (正式写手)

121-水手

谢谢回复,现在就是不知道这种情况是特例,还是普遍存在,坐等高手来指点~~~
昔日寒山问拾得曰:世间谤我、欺我、辱我、笑我、轻我、贱我、恶我、骗我、如何处治乎?拾得云:只是忍他、让他、由他、避他、耐他、敬他、不要理他、再待几年.
3楼2010-07-30 15:21:41
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

lsss

木虫 (正式写手)

121-水手

顶上去,等高人~~~~~~~~~~~~~
昔日寒山问拾得曰:世间谤我、欺我、辱我、笑我、轻我、贱我、恶我、骗我、如何处治乎?拾得云:只是忍他、让他、由他、避他、耐他、敬他、不要理他、再待几年.
4楼2010-07-31 07:37:44
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
普通表情 高级回复 (可上传附件)
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[硕博家园] 售SCI-T0P文章,我:8O.5.5.1.O.54,科目齐全,可+急 +3 v7Aev8ORQjin 2026-08-22 3/150 2026-08-23 20:58 by 0p9y1isJp2jM
[博后之家] 售SCI一区文章,我:8O5.5.1.O5.4,科目全,可伽急 +4 h4CP7TrQR8Lg 2026-08-22 4/200 2026-08-23 20:46 by 0p9y1isJp2jM
[公派出国] 售SCI文章,我:8O.5.5.1O.54,科目全,可十急 +4 2JOx3r2CYEgw 2026-08-21 7/350 2026-08-23 19:10 by lXgU0RvNTDC9
[考研] 售一区SCI文章T0P,我:8O.551.O54,科目全,可十急 +3 2JOx3r2CYEgw 2026-08-21 5/250 2026-08-23 18:55 by lXgU0RvNTDC9
[基金申请] 什么时候开奖? +9 CrisMessi 2026-08-18 10/500 2026-08-23 12:03 by 丶昵称占用
[硕博家园] 售SCI一区T0P文章,我:8.O55.1.O.54,科目全,可十急 +3 2JOx3r2CYEgw 2026-08-21 9/450 2026-08-23 10:44 by IXZuIJ2Q7OVy
[基金申请] 今天放榜吗? +15 布布和一二 2026-08-19 16/800 2026-08-23 09:55 by 张春生
[硕博家园] 售SCI一区T0P文章,我:8.O.55.1.O54,科目全,可伽急 +3 2JOx3r2CYEgw 2026-08-22 5/250 2026-08-23 07:41 by OEbVnUOu01ol
[考博] 售SCI一区T0P文章,我:8.O55.1.O.54,科目全,可十急 +3 2JOx3r2CYEgw 2026-08-21 10/500 2026-08-23 07:17 by OEbVnUOu01ol
[博后之家] 售SCI一区T0P文章,我:8.O.55.1.O54,科目全,可伽急 +3 DpSrDtM079iu 2026-08-22 5/250 2026-08-23 04:07 by OEbVnUOu01ol
[硕博家园] 售SCI一区文章,我:8O5.5.1.O5.4,科目全,可伽急 +3 2JOx3r2CYEgw 2026-08-22 7/350 2026-08-23 03:43 by OEbVnUOu01ol
[论文投稿] 售SCI一区T0P文章,我:8.O.55.1.O.5.4,科目全,可+急 +3 QTy3jDtz1uLt 2026-08-21 9/450 2026-08-23 03:04 by OEbVnUOu01ol
[基金申请] 93BebMhtakh前后11位开头都是大写 +7 且听虎啸 2026-08-17 8/400 2026-08-22 21:55 by 医学老男孩
[基金申请] 范进中举一文的中心思想 +3 炎黄贵胄 2026-08-22 4/200 2026-08-22 20:02 by mycsru
[基金申请] 只有每年这种时候来逛逛小木虫 +24 yaoyewhu2008 2026-08-20 26/1300 2026-08-22 17:43 by kammury
[基金申请] 人气不行了 +8 fansofjerry 2026-08-21 8/400 2026-08-22 16:30 by zyqchem
[基金申请] 看来今天不会放榜了? +8 chengyan1220 2026-08-21 11/550 2026-08-21 17:52 by dcqxinyang
[基金申请] 我面上完蛋了 +7 且听虎啸 2026-08-20 8/400 2026-08-21 12:31 by 酷酷墨镜
[论文投稿] 投稿咨询 +5 wwm09 2026-08-17 7/350 2026-08-21 10:11 by 期刊论文帮手
[基金申请] 朋友圈看到的 +6 wangzilk 2026-08-18 8/400 2026-08-19 10:55 by Haru815
信息提示
请填处理意见