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yangliu099新虫 (初入文坛)
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求文章~谢谢大家~
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3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. 文章题目如上~谢谢大家~ |
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yangliu099
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3,3-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice Yoon Hee Kim, MS 1, Hyuck-Se Kwon, MS 1, Dae Hwan Kim, MS 1, Eun Kyung Shin, MS 1, Young-Hee Kang, PhD 2, Jung Han Yoon Park, PhD 2, Hyun-Kyung Shin, PhD 1 2, Jin-Kyung Kim, PhD 1 * 1Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, South Korea 2Department of Food Science and Nutrition, Hallym University, Chuncheon, South Korea email: Jin-Kyung Kim (kimjin@hallym.ac.kr) *Correspondence to Jin-Kyung Kim, Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, 200-702 South Korea Funded by: Regional Innovation Center (RIC) program of the Ministry of Commerce, Industry, and Energy, Republic of Korea Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST); Grant Number: R01-2007-000-20164-0 Keywords inflammatory bowel diseases • colon cancer • 3,3-diindolylmethane Abstract Background: 3,3-Diindolylmethane (DIM) is a major in vivo product of acid-catalyzed oligomerization of indole-3-carbinol (I3C) derived from Brassica food plants. Although DIM is known as a chemopreventive and chemotherapeutic phytochemical, the effects of DIM on inflammation in vivo are still unknown. In the present study we investigated the antiinflammatory effects of DIM on experimental colitis and colitis-associated colorectal carcinogenesis. Methods: To determine if DIM has an antiinflammatory effect in vivo, we examined the therapeutic effects of DIM in dextran sodium sulfate (DSS)-induced experimental colitis and colitis-associated colon carcinogenesis induced by azoxymethane (AOM)/DSS in BALB/c mice. Results: Treatment with DIM significantly attenuated loss of body weight, shortening of the colon, and severe clinical signs in a colitis model. This was associated with a remarkable amelioration of the disruption of the colonic architecture and a significant reduction in colonic myeloperoxidase activity and production of prostaglandin E2, nitric oxide, and proinflammatory cytokines. Further, DIM administration dramatically decreased the number of colon tumors in AOM/DSS mice. Conclusions: These results suggest that DIM-mediated antiinflammatory action at colorectal sites may be therapeutic in the setting of inflammatory bowel disease and colitis-associated colon cancer. (Inflamm Bowel Dis 2009) -------------------------------------------------------------------------------- Received: 28 January 2009; Accepted: 7 February 2009 Digital Object Identifier (DOI) 10.1002/ibd.20917 About DOI |
2楼2010-07-15 11:33:32
