| 查看: 497 | 回复: 2 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
yangliu099新虫 (初入文坛)
|
[交流]
求文章~谢谢大家~
|
||
|
3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. 文章题目如上~谢谢大家~ |
回复此楼» 猜你喜欢
招收生物学/细胞生物学调剂
已经有4人回复
-
一志愿武汉理工，总分321，英一数二，求老师收留。
已经有5人回复
-
324求调剂
已经有8人回复
-
284求调剂
已经有12人回复
-
348求调剂
已经有3人回复
-
329求调剂
已经有7人回复
-
求调剂，一志愿 南京航空航天大学大学 ，080500材料科学与工程学硕
已经有4人回复
-
考研调剂
已经有9人回复
-
304材料求调剂
已经有4人回复
-
一志愿郑大085600，310分求调剂
已经有3人回复
yangliu099
新虫 (初入文坛)
- 应助: 0 (幼儿园)
- 金币: 280.5
- 散金: 15
- 帖子: 33
- 在线: 7.9小时
- 虫号: 563038
- 注册: 2008-05-24
- 专业: 抗肿瘤药物药理
3楼2010-07-15 12:02:22
jkf1860
木虫 (著名写手)
- 博学EPI: 6
- 应助: 1 (幼儿园)
- 金币: 2409.6
- 红花: 1
- 帖子: 1968
- 在线: 119.9小时
- 虫号: 316069
- 注册: 2007-03-03
- 性别: GG
- 专业: 橡胶及弹性体
|
3,3-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice Yoon Hee Kim, MS 1, Hyuck-Se Kwon, MS 1, Dae Hwan Kim, MS 1, Eun Kyung Shin, MS 1, Young-Hee Kang, PhD 2, Jung Han Yoon Park, PhD 2, Hyun-Kyung Shin, PhD 1 2, Jin-Kyung Kim, PhD 1 * 1Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, South Korea 2Department of Food Science and Nutrition, Hallym University, Chuncheon, South Korea email: Jin-Kyung Kim (kimjin@hallym.ac.kr) *Correspondence to Jin-Kyung Kim, Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, 200-702 South Korea Funded by: Regional Innovation Center (RIC) program of the Ministry of Commerce, Industry, and Energy, Republic of Korea Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST); Grant Number: R01-2007-000-20164-0 Keywords inflammatory bowel diseases • colon cancer • 3,3-diindolylmethane Abstract Background: 3,3-Diindolylmethane (DIM) is a major in vivo product of acid-catalyzed oligomerization of indole-3-carbinol (I3C) derived from Brassica food plants. Although DIM is known as a chemopreventive and chemotherapeutic phytochemical, the effects of DIM on inflammation in vivo are still unknown. In the present study we investigated the antiinflammatory effects of DIM on experimental colitis and colitis-associated colorectal carcinogenesis. Methods: To determine if DIM has an antiinflammatory effect in vivo, we examined the therapeutic effects of DIM in dextran sodium sulfate (DSS)-induced experimental colitis and colitis-associated colon carcinogenesis induced by azoxymethane (AOM)/DSS in BALB/c mice. Results: Treatment with DIM significantly attenuated loss of body weight, shortening of the colon, and severe clinical signs in a colitis model. This was associated with a remarkable amelioration of the disruption of the colonic architecture and a significant reduction in colonic myeloperoxidase activity and production of prostaglandin E2, nitric oxide, and proinflammatory cytokines. Further, DIM administration dramatically decreased the number of colon tumors in AOM/DSS mice. Conclusions: These results suggest that DIM-mediated antiinflammatory action at colorectal sites may be therapeutic in the setting of inflammatory bowel disease and colitis-associated colon cancer. (Inflamm Bowel Dis 2009) -------------------------------------------------------------------------------- Received: 28 January 2009; Accepted: 7 February 2009 Digital Object Identifier (DOI) 10.1002/ibd.20917 About DOI |
2楼2010-07-15 11:33:32
5