| 查看: 555 | 回复: 2 | |||
yangliu099新虫 (初入文坛)
|
[交流]
求文章~谢谢大家~
|
|
3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. 文章题目如上~谢谢大家~ |
回复此楼» 猜你喜欢
欢迎发来filecode的Mz6后的代码验证其规律
已经有123人回复
-
今天基金会出结果吗？20260819
已经有13人回复
-
时间戳变了，能看出什么问题？
已经有16人回复
-
filecode，4个jtjc了
已经有13人回复
-
为什么余额宝的年化利率越来越低？主要原因有哪些？
已经有5人回复
-
今天放榜没戏了吧
已经有5人回复
-
今天放榜吗？
已经有15人回复
-
filecode=后面第一个是大写字母
已经有12人回复
-
2027广东省杰青
已经有10人回复
-
朋友圈看到的
已经有8人回复
jkf1860
木虫 (著名写手)
- 博学EPI: 6
- 应助: 1 (幼儿园)
- 金币: 2409.6
- 红花: 1
- 帖子: 1968
- 在线: 119.9小时
- 虫号: 316069
- 注册: 2007-03-03
- 性别: GG
- 专业: 橡胶及弹性体
|
3,3-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice Yoon Hee Kim, MS 1, Hyuck-Se Kwon, MS 1, Dae Hwan Kim, MS 1, Eun Kyung Shin, MS 1, Young-Hee Kang, PhD 2, Jung Han Yoon Park, PhD 2, Hyun-Kyung Shin, PhD 1 2, Jin-Kyung Kim, PhD 1 * 1Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, South Korea 2Department of Food Science and Nutrition, Hallym University, Chuncheon, South Korea email: Jin-Kyung Kim (kimjin@hallym.ac.kr) *Correspondence to Jin-Kyung Kim, Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, 200-702 South Korea Funded by: Regional Innovation Center (RIC) program of the Ministry of Commerce, Industry, and Energy, Republic of Korea Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST); Grant Number: R01-2007-000-20164-0 Keywords inflammatory bowel diseases • colon cancer • 3,3-diindolylmethane Abstract Background: 3,3-Diindolylmethane (DIM) is a major in vivo product of acid-catalyzed oligomerization of indole-3-carbinol (I3C) derived from Brassica food plants. Although DIM is known as a chemopreventive and chemotherapeutic phytochemical, the effects of DIM on inflammation in vivo are still unknown. In the present study we investigated the antiinflammatory effects of DIM on experimental colitis and colitis-associated colorectal carcinogenesis. Methods: To determine if DIM has an antiinflammatory effect in vivo, we examined the therapeutic effects of DIM in dextran sodium sulfate (DSS)-induced experimental colitis and colitis-associated colon carcinogenesis induced by azoxymethane (AOM)/DSS in BALB/c mice. Results: Treatment with DIM significantly attenuated loss of body weight, shortening of the colon, and severe clinical signs in a colitis model. This was associated with a remarkable amelioration of the disruption of the colonic architecture and a significant reduction in colonic myeloperoxidase activity and production of prostaglandin E2, nitric oxide, and proinflammatory cytokines. Further, DIM administration dramatically decreased the number of colon tumors in AOM/DSS mice. Conclusions: These results suggest that DIM-mediated antiinflammatory action at colorectal sites may be therapeutic in the setting of inflammatory bowel disease and colitis-associated colon cancer. (Inflamm Bowel Dis 2009) -------------------------------------------------------------------------------- Received: 28 January 2009; Accepted: 7 February 2009 Digital Object Identifier (DOI) 10.1002/ibd.20917 About DOI |
2楼2010-07-15 11:33:32
yangliu099
新虫 (初入文坛)
- 应助: 0 (幼儿园)
- 金币: 280.5
- 散金: 15
- 帖子: 33
- 在线: 7.9小时
- 虫号: 563038
- 注册: 2008-05-24
- 专业: 抗肿瘤药物药理
3楼2010-07-15 12:02:22
