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¡¾×÷Õß(±ØÌî)¡¿ Takeshi Kono , a, , Tsukasa Taniia, Masayoshi Furukawaa, Nobuyuki Mizunoa, Shoji Taniguc ¡¾ÎÄÌâ(±ØÌî)¡¿ ¡¶Effect of tretinoin on collagen gel contraction induced by mouse 3T3 fibroblasts ¡· ¡¾ÆÚ¿¯Ãû,Äê·Ý,¾í(ÆÚ),ÆðÖ¹Ò³Âë(±ØÌî)¡¿ Journal of Dermatological Science Volume 2, Issue 1, January 1991, Pages 45-49 |
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Òø³æ (ÕýʽдÊÖ)
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²»ºÃÒâ˼£¬Ö»ÄÜÕÒµ½ÕªÒª¡£²»¹ýÄã¿ÉÒÔ¿´ÕâÆªÎÄÕµÄ×÷Õß·¢µÄÆäËûÎÄÕ£¬ÕÒµ½ËûµÄÓÊÏä»òÕßÁªÏµ·½Ê½£¬·¢ÓʼþË÷ÒªÕâÆªÎÄÕ¡£±§Ç¸ Abstract - selected Journal of Dermatological Science Volume 2, Issue 1, January 1991, Pages 45-49 -------------------------------------------------------------------------------- doi:10.1016/0923-1811(91)90041-U | How to Cite or Link Using DOI Copyright © 1991 Published by Elsevier Ireland Ltd. Cited By in Scopus (1) Permissions & Reprints Regular paper Effect of tretinoin on collagen gel contraction induced by mouse 3T3 fibroblasts This article is not included in your organization's subscription. However, you may be able to access this article under your organization's agreement with Elsevier. Takeshi Kono, a, , Tsukasa Taniia, Masayoshi Furukawaa, Nobuyuki Mizunoa, Shoji Taniguchia, Masamitsu Ishiia, Toshio Hamadaa and Katsutoshi Yoshizatob a Department of Dermatology, Osaka City University Medical School, Abeno-ku, Osaka, Japan b Developmental Biology Laboratory, Zoological Institute, Faculty of Science, Hiroshima University, Naka-ku, Hiroshima, Japan Received 6 December 1989; accepted 25 July 1990. Available online 21 April 2005. Abstract Balb/3T3 fibroblasts were cultured in type I collagen gel and the effects of tretinoin (all-trans-retinoic acid) were examined on cell growth and the gel contraction produced by cells. Cell proliferation was suppressed and the degree of gel contraction was enhanced by the addition of 10−7 and 10−6 M tretinoin. Growth and gel contractility of transformed cells derived from the Balb/3T3 cells were not influenced by this agent. Addition of 12-O-tetradecanoylphorbol ester, which is known to antagonize tretinoin in several biological processes, enhanced gel contraction synergistically with tretinoin. These results suggest that tretinoin influences cell-to-collagen interactions. Author Keywords: Collagen gel culture; Collagen, type I; Balb/3T3 cells; Cell growth; Tretinoin (all-trans-retinoic acid); 12-O-Tetradecanoylphorbol-13-acetate (TPA) Article Outline • References ![]() ![]() ![]() ![]() ![]() |
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