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[求助]
还是英文摘要
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DEVELOPMENTAL TOXICITY OF IBUPROFEN TREATED MICE The effect of ibuprofen – an anti-inflammatory, analgesic drug was tested on pregnant females at different developmental phases. The fetus was collected on 12th, 15th and 18th gestation days (gd). Embryos on the day of parturition and 5 day old new born were considered for experimental study. Ovary and uterus of the mother was also taken into account for histopathological examination. The adverse effects on pregnancy outcome included a significant reduction in the number of implantation and significant increase in percentage of post implantation loss. The body weight as well as physical characteristics varied due to the treatment at different phases of gestation. The concentrations of brain DNA and RNA of the fetus and the pups were also lower compared to controls. A major change in the histological architecture was seen in the sections of ovary and uterus of the mother. These findings suggest the susceptibility of the drug to the mother as well as to the embryo. |
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4楼2010-03-23 11:31:44
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