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montclimber

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[½»Á÷] ±»Synthetic Communications¾ÜÁË£¬ÓÐûÓиüºÃµÄÔÓÖ¾£¿

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Dear XXX:
>
>I regret to inform you that our reviewers have now considered your paper but unfortunately feel it unsuitable for publication in Synthetic Communications.   For your information I attach the reviewer comments at the bottom of this email.  I hope you will find them to be constructive and helpful.  You are of course now free to submit the paper elsewhere should you choose to do so.
>
>Thank you for considering Synthetic Communications. I hope the outcome of this specific submission will not discourage you from the submission of future manuscripts.
>
>Sincerely,
>Dr. XXX
>Associate Editor, Synthetic Communications
>>
>
>Reviewer(s)' Comments to Author:
>
>Reviewer: 1
>Comments to the Author
>    The synthesis of XXX is really neccessiry due to XXX have been served as the inhibitor of cellular nucleus topoisomerase I , protein kinase C as well as  checkpoint kinase.
>    Author reported that the XXX reaction can obtain better yield than XXX reported by .Anizon F,et al (J. Med. Chem. 1997, 40,3456-3465) and considered that possible reason of low yields may due to XXX.
>     However, author did not presented the correspounding data of solubility of XXX. Author failed to get the Anizon reported results. How did  author to review this results? Can author confirm  the Anizon reported results is not repeated result? If the Anizon reported results is a repeatable, This manuscript will lose publish value.
>    Reviewer suggest that author present more experiemental results to indicate that the solubility of XXX is a key factor effecting reaction yield. And confirm  the Anizon reported results is not a repeated result.
>     
>
>Reviewer: 2
>Comments to the Author
>This manuscript describes XXX. However, the same reaction with same reagent  had been reported in 1987 (J. Org. Chem. 1987, 52, 1177-1185). This paper is not recommended for a publication in Synthetic Communications.

Reviewer2 ˵µÄÕâÆªÎÄÏ×ÎÒÏÖÔÚûÓÐÈ«ÎÄ£¬µ«ÊÇÎÒÒ²»Ø¸´Á½Î»Éó¸åÈËÁË£¬ËµÁË×Ô¼ºµÄÀíÓÉ£º
For reviewer 1: In Anizon¡¯s article, there is no data available supporting the solubility of XXX. We had found it hard to dissolve in toluene when we carried out TLC testing. However, TLC results revealed an evident spot (fluorescent yellow) when the oxidative reaction took place in combinatorial solvents in relatively very short time. We did have observed a near 90% yield when we used a combinatorial solvent-- XXX, but not in pure toluene. Thus we guessed there might be a small mistake in Anizon¡¯s article. TLC could not give us actual figures, and maybe next time we should try HPLC.      

For reviewer 2: Actually we had reported XXX reaction of two compounds, not just XXX. We discovered that combinatorial solvents had improved solubility of XXX and the catalyst XXX had not been added during the cyclisation.

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[ Last edited by montclimber on 2010-3-23 at 14:36 ]
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